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Material Safety Data Sheet
Printing date 01/17/2008 Reviewed on 01/16/2008
DR
* 1 Identification of substance:
· Product details:
· Trade name: 2-D Rehydration/Sample Buffer 1
· Catalog or product number: 1632083
· Application of the substance / the preparation Laboratory chemicals
· Manufacturer/Supplier:
Bio-Rad Laboratories, Life Science Group
2000 Alfred Nobel Drive
Hercules, California 94547 (510)741-1000
· Information department: Technical services, customer support.
· Emergency information:
1(800)424-9300 Use only in the event of a CHEMICAL EMERGENCY involving a SPILL, LEAK, FIRE, EXPLOSION or ACCIDENT.
510-741-1000
* 2 Composition/Information on components:
· Chemical characterization
· Description: Mixture of the substances listed below with non-hazardous additions.
· Listing of dangerous and non-hazardous components:
CAS: 57-13-6
EINECS: 200-315-5
RTECS: YR 6250000
urea 50-100%
CAS: 62-56-6
EINECS: 200-543-5
thiourea
Carc. Cat. 3, Repr. Cat. 3; Xn, N; R 22-40-51/53-63
20-35%
tetradecanoyamidapropyl-dimethylammonio propanesulfonate (AS B-14)
Xi; R 36/37/38
1.0-2.5%
· Additional information For the wording of the listed risk phrases refer to section 15.
3 Hazards identification
· Emergency overview:
Contains a component that may be fetotoxic and/or teratogenic.
Xn Harmful
N Dangerous for the environment
· Routes of exposure: Ingestion
· Information pertaining to particular dangers for man and environment
The product has to be labelled due to the calculation procedure of the "General Classification guideline for preparations of the EU" in
the latest valid version.
R 22 Harmful if swallowed.
R 40 Limited evidence of a carcinogenic effect.
R 51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R 63 Possible risk of harm to the unborn child
· Classification system
The classification was made according to the latest editions of the EU-lists, and expanded upon from company and literature data.
4 First aid measures
· General information
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
(Contd. on page 2)
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Material Safety Data Sheet
Printing date 01/17/2008 Reviewed on 01/16/2008
Trade name: 2-D Rehydration/Sample Buffer 1
(Contd. of page 1)
DR
· After inhalation Supply fresh air; consult doctor in case of complaints.
· After skin contact Generally the product does not irritate the skin.
· After eye contact Rinse opened eye for several minutes under running water.
· After swallowing Immediately call a doctor.
5 Fire fighting measures
· Suitable extinguishing agents CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
· Protective equipment: No special measures required.
6 Accidental release measures
· Person-related safety precautions: Not required
· Measures for environmental protection:
Inform respective authorities in case of seepage into water course or sewage system.
Do not allow to enter sewers/ surface or ground water.
· Measures for cleaning/collecting: Dispose contaminated material as waste according to item 13.
* 7 Handling and storage
· Handling
· Information for safe handling:
Prevent formation of dust.
No special precautions are necessary if used correctly.
· Information about protection against explosions and fires: No special measures required.
· Storage
· Requirements to be met by storerooms and receptacles: According to product specification
· Information about storage in one common storage facility: Not required.
· Further information about storage conditions: None.
* 8 Exposure controls and personal protection
· Additional information about design of technical systems: No further data; see item 7.
· Components with limit values that require monitoring at the workplace:
57-13-6 urea
WEEL () 10 mg/m³
· Additional information: The lists that were valid during the creation were used as basis.
· Personal protective equipment
· General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Wash hands before breaks and at the end of work.
· Breathing equipment:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective
device that is independent of circulating air.
· Protection of hands: Protective gloves.
· Material of gloves Synthetic gloves
(Contd. on page 3)
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Material Safety Data Sheet
Printing date 01/17/2008 Reviewed on 01/16/2008
Trade name: 2-D Rehydration/Sample Buffer 1
(Contd. of page 2)
DR
· Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
· Eye protection: Safety glasses
* 9 Physical and chemical properties:
· General Information
Form: Solid.
Color: Whitish
Odor: Odorless
· Change in condition
Melting point/Melting range: undetermined
Boiling point/Boiling range: undetermined
· Flash point: Not applicable
· Ignition temperature: 440°C
· Auto igniting: Product is not selfigniting.
· Danger of explosion: Product does not present an explosion hazard.
· Density: Not determined
· Solubility in / Miscibility with
Water: Fully miscible
· pH-value at 20°C: >10
· Solvent content:
· Organic solvents: 0.0 %
· Solids content: 100.0 %
10 Stability and reactivity
· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
· Dangerous reactions No dangerous reactions known
· Dangerous products of decomposition: No dangerous decomposition products known
11 Toxicological information
· Acute toxicity:
· LD/LC50 values for hazardous components per OSHA criteria:
57-13-6 urea
Oral LD50 14500 mg/kg (rat)
62-56-6 thiourea
Oral LD50 1750 mg/kg (rat)
Dermal LD50 2800 mg/kg (rbt)
· Primary irritant effect:
· on the skin: No irritant effect.
(Contd. on page 4)
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Material Safety Data Sheet
Printing date 01/17/2008 Reviewed on 01/16/2008
Trade name: 2-D Rehydration/Sample Buffer 1
(Contd. of page 3)
DR
· on the eye: No irritant effect.
· Sensitization: No sensitizing effects known.
· Additional toxicological information:
The product shows the following dangers according to the calculation method of the General EU Classification Guidelines for
Preparations as issued in the latest version:
Harmful
* 12 Ecological information:
· Ecotoxical effects:
· Remark: Toxic for fish
· General notes:
Water hazard class 2 (Self-assessment): hazardous for water.
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Also poisonous for fish and plankton in water bodies.
Toxic for aquatic organisms
13 Disposal considerations
· Product:
· Recommendation
Hand over to hazardous waste disposers.
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
· Uncleaned packagings:
· Recommendation: Disposal must be made according to official regulations.
· Recommended cleansing agent: Water, if necessary with cleansing agents.
* 14 Transport information
· DOT regulations:
· Hazard class: 9
· Identification number: UN3077
· Packing group: III
· Proper shipping name (technical name): ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (thiourea)
· Label 9
· Land transport ADR/RID (cross-border)
· ADR/RID class: 9 Miscellaneous dangerous substances and articles
· Danger code (Kemler): 90
· UN-Number: 3077
· Packing group: III
· Label 9
· Description of goods: 3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (thiourea)
· Maritime transport IMDG:
· IMDG Class: 9
· UN Number: 3077
· Label 9
· Packing group: III
(Contd. on page 5)
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Material Safety Data Sheet
Printing date 01/17/2008 Reviewed on 01/16/2008
Trade name: 2-D Rehydration/Sample Buffer 1
(Contd. of page 4)
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· EMS Number: F-A,S-F
· Marine pollutant: No
· Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (thiourea)
· Air transport ICAO-TI and IATA-DGR:
· ICAO/IATA Class: 9
· UN/ID Number: 3077
· Label 9
· Packing group: III
· Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (thiourea)
* 15 Regulations
· SARA (Superfund Amendents and Reauthorization Act of 1986 - USA)
· Section 302/304 (40CFR355.30 / 40CFR355.40):
None of the ingredients is listed.
· Section 313 (40CFR372.65):
62-56-6 thiourea
· TSCA (Toxic Substances Control Act):
57-13-6 urea
62-56-6 thiourea
77-86-1 Tris(hydroxymethyl)aminomethane
· California Proposition 65:
· Chemicals known to cause cancer:
62-56-6 thiourea
· Cancerogenity categories
· EPA (Environmental Protection Agency)
None of the ingredients is listed.
· IARC (International Agency for Research on Cancer)
62-56-6 thiourea 3
· NTP (National Toxicology Program)
62-56-6 thiourea R
· TLV (Threshold Limit Value established by ACGIH)
None of the ingredients is listed.
· MAK (German Maximum Workplace Concentration)
62-56-6 thiourea 3
· NIOSH-Ca (National Institute for Occupational Safety and Health)
None of the ingredients is listed.
· OSHA-Ca (Occupational Safety & Health Administration)
None of the ingredients is listed.
· Markings according to EU guidelines:
The product has been classified and marked in accordance with EU Directives / Ordinance on Hazardous Materials
(Contd. on page 6)
USA
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Material Safety Data Sheet
Printing date 01/17/2008 Reviewed on 01/16/2008
Trade name: 2-D Rehydration/Sample Buffer 1
(Contd. of page 5)
DR
· Code letter and hazard designation of product:
Xn Harmful
N Dangerous for the environment
· Hazard-determining components of labelling:
thiourea
· Risk phrases:
22 Harmful if swallowed.
40 Limited evidence of a carcinogenic effect.
51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
63 Possible risk of harm to the unborn child
· Safety phrases:
22 Do not breathe dust.
25 Avoid contact with eyes.
36/37 Wear suitable protective clothing and gloves.
57 Use appropriate container to avoid environmental contamination.
60 This material and its container must be disposed of as hazardous waste.
· National regulations
Class Share in %
I 20-35
· Water hazard class: Water hazard class 2 (Self-assessment): hazardous for water.
16 Other information:
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and
shall not establish a legally valid contractual relationship.
· Department issuing MSDS: Environmental Health and Safety.
· Contact:
Life Science Group, Environmental Health and Safety, 2000 Alfred Nobel Drive, Hercules, California, 94547: 1(510) 741-1000
Diagnostic Group, Environmental Health and Safety, 4000 Alfred Nobel Drive, Hercules, California, 94547: 1(510) 724-7000
· * Data compared to the previous version altered.
USA