SIGMA CHEMICAL CO -- R9009, RIBONUCLEASE A FROM BOVINE (SUPDAT) ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 01/01/1999 MSDS Num: CJVPQ LIIN: 00N092677 Product ID: R9009, RIBONUCLEASE A FROM BOVINE (SUPDAT) MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Box: 14508 City: ST LOUIS MO 63178 Phone: 1-314-771-5765 ======================================================= Ingredients ======================================================= Cas: 9001-99-4 RTECS #: RF0760000 Name: RIBONUCLEASE Percent by Wt: 100. ======================================================= Health Hazards Data ======================================================= Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. PROLONGED OR REPEATED EXPOSURE MAY CAUSE AL LERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. THE TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES. CALL A PHYSICIAN. IF INHAL ED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT, CALL A PHYSICIAN. IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING THE EYELIDS WITH FINGERS. CALL A PH YSICIAN. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR PROTECTIVE EQUIPMENT. SPILLED MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND REMOVED. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: CAUTION: AVOID CONTACT AND INHALATION. AVOID CONTACT WITH EYES, SKIN AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. Other Precautions: KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS. Fire Fighting Procedures: WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES. Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: NIOSH APPROVED RESPIRATOR. Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: COMPATIBLE CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: ANSI APPROVED EYE WASH & DELUGE SHOWER (FP N). Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. Supplemental Safety and Health: MFR TRADE NAME/PART NO: PANCREAS MOLECULAR BIOLOGY REAGENT. ======================================================= Physical/Chemical Properties ======================================================= Solubility in Water: SOLUBLE Appearance and Odor: SOLID. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Hazardous Decomposition Products: NATURE OF DECOMPOSITION PRODUCTS NOT KNOWN. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= Toxicological Information: RTECS #: RF0760000. NUCLEASE, RIBO-. TOXICITY DATA: IPR-RAT LD50:392 MG/KG. 54IIAL -,56,1985. SCU-RAT LD50:290 MG/KG. 54IIAL 0,56,1985. IMS-RAT LD50:310 MG/KG. 54IIAL -,56,1985. IPR-MUS LD50:250 MG/KG. 54IIAL -,,56,1985. IMS-MUS LD50:355 M G/KG. 54IIAL -,1985. ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: REVIEWS, STANDARDS, AND REGULATIONS. OEL=MAK. EPA TSCA SECTION 8(B) CHEMICAL INVENTORY. ======================================================= Other Information ======================================================= Other Information: INGREDIENT INFORMATION: EC NO: 232-646-6. LABEL PRECAUTIONARY STATEMENTS: CAUTION: AVOID CONTACT AND INHALATION. ======================================================= HAZCOM Label ======================================================= Product ID: R9009, RIBONUCLEASE A FROM BOVINE (SUPDAT) Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY PO Box: 14508 City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 12/06/1999 Status Code: A Origination Code: F Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: CAUTION Respiratory Protection IND: YES Health Hazard: Slight Contact Hazard: Slight Fire Hazard: Slight Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. CHRONIC: PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.