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Laboratory Products Safety Products Services Contact Us Customer Service GJS Mass Measurement 1-877-627-7225 Instrument Service 1-800-267-6633 Mailing Addresses Corporate Profile Employment Global Links President's Message Quality Management Policy Certificates of Analysis Material Safety Data Sheets Site Search Product Search **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: Rotenone, 97% Catalog Numbers: AC132370000, AC132370050, AC132370250 Synonyms: (-)-Rotenone(1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6ah)- one, 1,2,12,12a-tetrahydro; 5'-beta-Rotenone; Company Identification (Europe): Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium Company Identification (USA): Acros Organics One Reagent Lane Fairlawn, NJ 07410 For information in North America, call: 800-ACROS-01 For information in Europe, call: 0032(0) 14575211 For emergencies in the US, call CHEMTREC: 800-424-9300 For emergencies in Europe, call: 0032(0) 14575299 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 83-79-4 |Rotenone | 97 | 201-501-9 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: T Risk Phrases: 25 36/37/38 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Toxic if swallowed. Irritating to eyes, respiratory system and skin.Light sensitive.Air sensitive.Mutagen. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Ingestion: Harmful if swallowed. Ingestion may cause irritation of the digestive tract with abdominal pain, vomiting, diarrhea, numbness of the oral mucous membrane, slow or irregular pulse, incoordination, and muscle tremors. Inhalation: Causes respiratory tract irritation. Inhalation of large amounts may cause respiratory stimulation, followed by respiratory depression, convulsions and possible death due to respiratory paralysis. This product is more toxic when inhaled than when ingested. Chronic: Prolonged or repeated skin contact may cause dermatitis. Prolonged or repeated eye contact may cause conjunctivitis. May cause liver and kidney damage. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. Exposure to large doses may cause central nervous system depression. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Wash mouth out with water. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire. Use water spray, dry chemical, carbon dioxide, or chemical foam. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Store protected from light. Handle under an inert atmosphere. Store protected from air. Use only in a chemical fume hood. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store protected from light. Store under an inert atmosphere. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR :1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Powder Appearance: slightly yellow Odor: odorless pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate: Not available. Viscosity: Not available. Boiling Point: 210 - 220 deg C @ 0.50mm Hg Freezing/Melting Point: 165 - 166 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility: insoluble Specific Gravity/Density: 1.27 @ 20C Molecular Formula: C23H22O6 Molecular Weight: 394.41 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, light, dust generation, exposure to air, excess heat. Incompatibilities with Other Materials: Strong oxidizing agents, alkalis, air. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 83-79-4: DJ2800000 LD50/LC50: CAS# 83-79-4: Draize test, rabbit, eye: 1% Mild; Oral, mouse: LD50 = 2800 ug/kg; Oral, rat: LD50 = 60 mg/kg; Skin, rabbit: LD50 = >1 gm/kg; Skin, rat: LD50 = >940 mg/kg. Carcinogenicity: Rotenone - ACGIH: A4 - Not Classifiable as a Human Carcinogen Epidemiology: No information available. Teratogenicity: Oral, rat: TDLo = 50 mg/kg (female 6-15 day(s) after conception) Specific Developmental Abnormalities - musculoskeletal system.; Oral, rat: TDLo = 98 mg/kg (female 6-15 day(s) after conception) Effects on Newborn - live birth index (measured after birth). Reproductive Effects: Oral, rat: TDLo = 100 mg/kg (female 6-15 day(s) after conception) Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) and Fertility - litter size (e.g. # fetuses per litter; measured before birth).; Oral, rat: TDLo = 2960 ug/kg (female 6-9 day(s) after conception) Maternal Effects - uterus, cervix, vagina. Neurotoxicity: No information available. Mutagenicity: Oral, rat: TDLo = 3245 mg/kg/2Y-C (Tumorigenic - equivocal tumorigenic agent by RTECS criteria - Endocrine - tumors).; Intraperitoneal, rat: TDLo = 71 mg/kg/42D-I (Tumorigenic - neoplastic by RTECS criteria - Skin and Appendages - tumors).; Oral, rat: TD = 3285 mg/kg/2Y-C (Tumorigenic - equivocal tumorigenic agent by RTECS criteria - Endocrine - thyroid tumors).; DNA Damage: Rat, Liver = 15 umol/L.; Mutation in Mammalian Somatic Cells: Mouse, Lymphocyte = 250 ug/L. Other Studies: Standard Draize test: Administration into the eye (rabbit) = 1% (Mild). **** SECTION 12 - ECOLOGICAL INFORMATION **** Ecotoxicity: Fish: Fathead Minnow: LC50 = 0.142 mg/L; 96 Hr; Static bioassayFish: Rainbow trout: LC50 = 0.031 mg/L; 96 Hr; Static bioassay at 12C (pH 7.2-7.5)Fish: Bluegill/Sunfish: LC50 = 0.023 mg/L; 96 Hr; Static bioassay at 24C (pH 7.2-7.5)Water flea Daphnia: EC50 = 0.0037 mg/L; 48 Hr; Unspecified **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.* Hazard Class: 6.1 UN Number: 2811 Packing Group: III Canadian TDG Shipping Name: TOXIC SOLID ORGANIC NOS (ROTENONE) Hazard Class: 6.1 UN Number: UN2811 **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 83-79-4 is not listed on the TSCA inventory. It is for research and development use only. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE Rotenone can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T Risk Phrases: R 25 Toxic if swallowed. R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 22 Do not breathe dust. S 24/25 Avoid contact with skin and eyes. S 36 Wear suitable protective clothing. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 83-79-4: No information available. United Kingdom Occupational Exposure Limits CAS# 83-79-4: OES-United Kingdom, TWA 5 mg/m3 TWA CAS# 83-79-4: OES-United Kingdom, STEL 10 mg/m3 STEL Canada CAS# 83-79-4 is listed on Canada's DSL List. CAS# 83-79-4 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 83-79-4: OEL-AUSTRALIA:TWA 5 mg/m3 OEL-BELGIUM:TWA 5 mg/m3 OEL-DENMARK:TWA 5 mg/m3 OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3 OEL-GERMANY:TWA 5 mg/m3 OEL-THE NETHERLANDS:TWA 5 mg/m3 OEL-THE PHILIPPINES:TWA 5 mg/m3 OEL-SWITZERLAND:TWA 5 mg/m3 OEL-TURKEY:TWA 5 mg/m3 OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 JAN9 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 5/10/1999 Revision #1 Date: 8/02/2000 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------