Material Safety Data Sheet **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: Tannic Acid Catalog Numbers: S80215, A310 500, A310-500, A310500, S80215-1 Synonyms: Gallotannin; Glycerite; Gallotannic acid Company Identification: Fisher Scientific 1 Reagent Lane Fairlawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 1401-55-4 |Tannic Acid | 100 | 215-753-2 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: None Listed. Risk Phrases: None Listed. **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. May result in corneal injury. Skin: May cause skin irritation. May be absorbed through the skin in harmful amounts. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. Inhalation: Dust is irritating to the respiratory tract. Chronic: Chronic ingestion may cause liver damage. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid if irritation or symptoms occur. Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. Notes to Physician: **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing Media: Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or appropriate foam. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Store protected from light. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Powder Appearance: yellow-brown Odor: faint odor pH: Weak acid in water. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Decomposes Autoignition Temperature: 980 deg F ( 526.67 deg C) Flash Point: 390 deg F ( 198.89 deg C) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: 218 deg C Solubility: Completely soluble in water Specific Gravity/Density: Not available. Molecular Formula: C76H52O46 Molecular Weight: 1700.3364 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation. Incompatibilities with Other Materials: Strong oxidizing agents; strong bases. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, acrid smoke and fumes. Hazardous Polymerization: Will not occur. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 1401-55-4: FM3015000 PY7955000 UZ3400000 WU7185000 WW5075000 LD50/LC50: CAS# 1401-55-4: Oral, rabbit: LD50 = 5 gm/kg; Oral, rat: LD50 = 2260 mg/kg. Carcinogenicity: Tannic Acid - IARC: Group 3 carcinogen Epidemiology: No epidemiological studies or case reports of human exposure were available to the IARC working group. Per IARC, Tannic acid produced liver tumors in rats and mice following subcutaneous injection. Teratogenicity: TDLo(Subcutaneous, mouse) = 750 mg/kg/12W-I; Liver - tumors Reproductive Effects: No information available. Neurotoxicity: No information available. Mutagenicity: No information available. Other Studies: Tannic acid administered via the intraperitoneal or subcutaneous routes was found to accumulate in the liver and cause necrosis in rats. In autopsied human burn cases, liver necrosis attributable to absorption of tannic acid were observed. Eight deaths due to acute liver failure have been suggested to be associated with the use of barium enemas containing tannic acid. **** SECTION 12 - ECOLOGICAL INFORMATION **** Ecotoxicity: Fish: Mosquito Fish: LC50 = 37 mg/L; 96 Hr.; Unspecified **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT No information available Canadian TDG No information available. **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 1401-55-4 is listed on the TSCA inventory. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE Tannic Acid can be found on the following state right to know lists: California. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: WGK (Water Danger/Protection) CAS# 1401-55-4: 1 United Kingdom Occupational Exposure Limits Canada CAS# 1401-55-4 is listed on Canada's DSL List. CAS# 1401-55-4 is not listed on Canada's Ingredient Disclosure List. Exposure Limits **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 6/23/1999 Revision #3 Date: 8/02/2000 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------