SIGMA-ALDRICH CHEMICAL CO -- TETRACYCLINE HYDROCHLORIDE CRYSTALLINE, T3383 ======================================================= MSDS Safety Information ======================================================= FSC: 6810 MSDS Date: 03/16/1999 MSDS Num: CJPJB LIIN: 00N091811 Product ID: TETRACYCLINE HYDROCHLORIDE CRYSTALLINE, T3383 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA-ALDRICH CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Ingredients ======================================================= Cas: 64-75-5 Name: TETRACYCLINE HYDROCHLORIDE ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: LD50:(ORAL,RAT) 6443 MG/KG & TOX INFO Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. CAUSES EYE AND SKIN IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. PROLONGED OR REPEATED EXPOSUR E MAY CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. EXPOSURE CAN CAUSE: NAUSEA, VOMITING, DIARRHEA. CHRONIC: POSSIBLE RISK OF CONGENITAL MALFORMATION IN THE FETUS. TARGET ORGAN(S): LIVER, TEETH, BONES. TO THE BEST OF MFR'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. Explanation Of Carcinogenicity: NTP CARCINOGENESIS STUDIES (FEED); NO EVIDENCE: MOUSE, RAT NTPTR NTP-TR-363,89. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED CLOTHING AND SH OES. WASH CONTAMINATED CLOTHING BEFORE REUSE. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATE R PROVIDED PERSON IS CONSCIOUS. CALL MD. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP TIGHTLY CLOSED. STORE IN A COOL, DRY PLACE. Other Precautions: HARMFUL. POSSIBLE RISK OF HARM TO THE UNBORN CHILD. MAY CAUSE HARM TO BREASTFED BABIES. IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN. DANGER OF CUMULATIVE EFFECTS. POSSIBLE SENSITIZER. IN CASE OF A CCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW LABEL WHERE POSSIBLE). ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS. Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: USE ONLY IN A CHEMICAL FUME HOOD. Protective Gloves: CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: ANSI APPROVED EYE WASH & DELUGE SHOWER (FP N). WEAR SUITABLE OTHER PROTECTIVE CLOTHING. Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. ======================================================= Physical/Chemical Properties ======================================================= Melt/Freeze Pt: >220.C, 428.F M.P/F.P Text: 220C - 223C Appearance and Odor: SOLID. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Stability Condition To Avoid: MAY DISCOLOR ON EXPOSURE TO LIGHT. Materials To Avoid: STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: TOXIC FUME OF: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES, HYDROGEN CHLORIDE GAS. Hazardous Polymerization Indicator: NO Conditions To Avoid Polymerization: WILL NOT OCCUR. ======================================================= Toxicological Information ======================================================= Toxicological Information: LD50:(ORAL,RAT) 6443 MG/KG - TXAPA9 18,185,1971; LD50:(IPR,RAT) 318 MG/KG - GNRIDX 2,26,1968; LD50:(SCU,RAT) 700 MG/KG - TXAPA9 9,445,1966; LD50:(IVN,RAT) 128 MG/KG - FRPSAX 10,197,1955; LD50:(ORAL,MU S) 2759 MG/KG - JPPMAB 16,33,1964; LD50:(IPR,MUS) 368 MG/KG - JPPMAB 16,33,1964; LD50:(IVN,MUS) 157 MG/KG - FRPSAX 10,197,1955; LD50:(UNR,MUS) 105 MG/KG - 40YJAX -,55,1979. TARGET ORGAN DATA: SENSE OR GANS & SPECIAL SENSES (TASTE FUNC); GI (HYPERMOTILITY, DIARR); MATERNAL EFTS (UTERUS, CERVIX, VAGINA); EFTS ON FERTILITY (POST-IMPLANTATION MORTALITY, ABORTION); EFTS ON EMBRYO/FETUS (EXTRA EMBRYONIC STRUCTURES, FETOTOXICITY, (OTHER INFO) ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Sara Title III Information: THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS. Federal Regulatory Information: REVIEWS, STANDARDS AND REGULATIONS: OEL=MAK. NOHS 1974: HZD 83550; NIS 2; TNF 474; NOS 2; TNE 1795. NOES 1983; HZD 83550; NIS 4; TNF 680; NOS 15; TNE 22901; TFE 17276. EPA TSCA SECTION 8(B) CHEMICAL I NVENTORY. State Regulatory Information: CALIFORNIA PROPOSITION 65 REPRODUCTIVE HAZARD. THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE DEVELOPMENTAL TOXICITY. ======================================================= Other Information ======================================================= Other Information: MFR'S INFO: CUST #: 0-495-05107; PO #: CC/99C22490805; EC #: 200-593-8. -- TOX INFO: FETAL DEATH, OTHER EFFECTS TO EMBRYO OR FETUS); SPECIFIC DEVELOPMENTAL ABNORMALITITES (MUSCULOSKELETAL SYSTEM). ONL Y SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ======================================================= HAZCOM Label ======================================================= Product ID: TETRACYCLINE HYDROCHLORIDE CRYSTALLINE, T3383 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 08/09/1999 Status Code: A Origination Code: F Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: CAUTION Respiratory Protection IND: YES Health Hazard: Slight Contact Hazard: Slight Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. CAUSES EYE AND SKIN IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. EXPOSURE CAN CAUSE: NAUSEA, VOMITING, DIARRHEA. CHRONIC: PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. POSSIBLE RISK OF CONGENITAL MALFORMATION IN THE FETUS. TARGET ORGAN(S): LIVER , TEETH, BONES. TO THE BEST OF MFR'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.