SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 10/10/2008
Date Updated: 01/30/2006
Version 1.3
Section 1 - Product and Company Information
Product Name (+/-)-THALIDOMIDE
Product Number T144
Brand SIGMA
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
(+-)-THALIDOMIDE 50-35-1 No
Formula C13H10N2O4
Synonyms Algosediv * Asidon 3 * Asmadion * Asmaval *
Bonbrain * Contergan * Corronarobetin *
2,6-Dioxo-3-phthalimidopiperidine *
N-(2,6-Dioxo-3-piperidyl)phthalimide * Distaval *
Ectiluran * Enterosediv * Gastrinide *
Glutarimide, 2-phthalimido- * Grippex * Hippuzon
* Imida-lab * Imidan (peyta) * Imidene *
1H-Isoindole-1,3(2H)-dione,
2-(2,6-dioxo-3-piperidinyl)- * Isomin * K 17 *
Kevadon * Neaufatin * NeO * Nibrol * Noctosediv *
Noxodyn * NSC-66847 * Pangul * Pantosediv *
alpha-Phthalimidoglutarimide *
alpha-(N-Phthalimido)glutarimide *
3-Phthalimidoglutarimide * N-Phthaloylglutamimide
* N-Phthalylglutamic acid imide *
N-Phthalyl-glutaminsaeure-imid (German) *
alpha-N-Phthalylglutaramide * Poly-giron *
Polygripan * Predni-sediv * Pro-Bam M * Profarmil
* Psycholiquid * Psychotablets * Quetimid *
Quietoplex * Sandormin * Sedalis sedi-lab *
Sedimide * Sedin * Sedisperil * Sedoval *
Shin-naito S * Shinnibrol * Sleepan * Slipro *
Softenil * Softenon * Talargan * Talimol *
(+-)-Thalidomide * Yodomin
RTECS Number: TI4375000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic.
May cause harm to the unborn child. May cause heritable genetic
damage. Possible risk of impaired fertility. Toxic if swallowed.
Harmful in contact with skin.
Calif. Prop. 65 developmental hazard.
HMIS RATING
HEALTH: 4
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
FLAMMABILITY: 0
REACTIVITY: 0
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
EXPOSURE HAZARD(S)
Material: Not to be handled by women of child-bearing age.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
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rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face particle respirator type N100 (US) or
type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a
full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Color: White
Property Value At Temperature or Pressure
Molecular Weight 258.2 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 239.0 - 241.0 °C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
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Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Toxic if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
TOXICITY DATA
Oral
Rat
113 mg/kg
LD50
Skin
Rat
1550 mg/kg
LD50
Intraperitoneal
Rat
>6 GM/KG
LD50
Oral
Mouse
2000 mg/kg
LD50
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Subcutaneous
Mouse
>5 GM/KG
LD50
CHRONIC EXPOSURE - CARCINOGEN
Species: Mouse
Route of Application: Subcutaneous
Dose: 34 GM/KG
Exposure Time: 57W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application. Lungs,
Thorax, or Respiration:Tumors.
CHRONIC EXPOSURE - TERATOGEN
Result: May cause congenital malformation in the fetus.
Species: Woman
Dose: 2 MG/KG
Route of Application: Oral
Exposure Time: (30D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Woman
Dose: 17500 UG/KG
Route of Application: Oral
Exposure Time: (1-5W PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Woman
Dose: 2 MG/KG
Route of Application: Oral
Exposure Time: (29D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Woman
Dose: 16 MG/KG
Route of Application: Oral
Exposure Time: (28-35D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rat
Dose: 560 MG/KG
Route of Application: Oral
Exposure Time: (14D MALE)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (7-11D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
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Musculoskeletal system.
Species: Rat
Dose: 1050 MG/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord). Effects on Embryo or Fetus:
Fetal death.
Species: Rat
Dose: 28 GM/KG
Route of Application: Oral
Exposure Time: (3D MALE/3D PRE-22D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Urogenital system.
Species: Rat
Dose: 200 MG/KG
Route of Application: Oral
Exposure Time: (15D PRE)
Result: Specific Developmental Abnormalities: Skin and skin
appendages. Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 1200 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9-11D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Musculoskeletal system. Specific Developmental Abnormalities:
Central nervous system.
Species: Rat
Dose: 15 MG/KG
Route of Application: Intravenous
Exposure Time: (9-14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 45 MG/KG
Route of Application: Intravenous
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rat
Dose: 1700 MG/KG
Route of Application: Unreported
Exposure Time: (6-22D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 155 MG/KG
Route of Application: Oral
Exposure Time: (7-11D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
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system.
Species: Mouse
Dose: 25 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 100 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (13D PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
Species: Mouse
Dose: 2 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (11-12D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Dog
Dose: 2 GM/KG
Route of Application: Unreported
Exposure Time: (20-24D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Dog
Dose: 250 MG/KG
Route of Application: Unreported
Exposure Time: (20-24D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Monkey
Dose: 10 MG/KG
Route of Application: Oral
Exposure Time: (28D PREG)
Result: Specific Developmental Abnormalities: Eye, ear.
Species: Monkey
Dose: 60 MG/KG
Route of Application: Oral
Exposure Time: (24-26D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Species: Cat
Dose: 110 MG/KG
Route of Application: Oral
Exposure Time: (10-20D PREG)
Result: Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Effects on Embryo or Fetus: Fetal death.
Species: Rabbit
Dose: 450 MG/KG
Route of Application: Oral
Exposure Time: (7-9D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
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(including nose and tongue). Specific Developmental
Abnormalities: Respiratory system. Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rabbit
Dose: 400 MG/KG
Route of Application: Oral
Exposure Time: (7-16D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities. Effects on Embryo or Fetus: Fetal
death. Effects on Newborn: Biochemical and metabolic.
Species: Rabbit
Dose: 833 MG/KG
Route of Application: Oral
Exposure Time: (6-11D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Gastrointestinal system.
Species: Rabbit
Dose: 125 MG/KG
Route of Application: Oral
Exposure Time: (8-12D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rabbit
Dose: 1500 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-20D PREG)
Result: Specific Developmental Abnormalities: Body wall.
Specific Developmental Abnormalities: Other developmental
abnormalities.
Species: Rabbit
Dose: 1700 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1-17D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rabbit
Dose: 1800 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3-20D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Specific Developmental Abnormalities: Craniofacial (including
nose and tongue).
Species: Rabbit
Dose: 12500 UG/KG
Route of Application: Intravenous
Exposure Time: (8-12D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Body wall.
Specific Developmental Abnormalities: Musculoskeletal system.
Species: Rabbit
Dose: 900 MG/KG
Route of Application: Unreported
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Exposure Time: (7-12D PREG)
Result: Specific Developmental Abnormalities: Body wall.
Specific Developmental Abnormalities: Gastrointestinal system.
Species: Rabbit
Dose: 1050 MG/KG
Route of Application: Unreported
Exposure Time: (7-13D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rabbit
Dose: 500 MG/KG
Route of Application: Unreported
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Pig
Dose: 550 MG/KG
Route of Application: Oral
Exposure Time: (12-33D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Hamster
Dose: 300 MG/KG
Route of Application: Oral
Exposure Time: (8D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mammal
Dose: 1500 MG/KG
Route of Application: Oral
Exposure Time: (8-12D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - MUTAGEN
Result: May alter genetic material.
Species: Human
Dose: 1 MG/L
Cell Type: lymphocyte
Mutation test: Cytogenetic analysis
Species: Rat
Route: Intraperitoneal
Dose: 80 MG/KG
Mutation test: Unscheduled DNA synthesis
Species: Rat
Route: Intraperitoneal
Dose: 80 MG/KG
Mutation test: Other mutation test systems
Species: Rat
Route: Oral
Dose: 7600 MG/KG
Exposure Time: 30D
Mutation test: Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
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Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (10-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 22 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 45 MG/KG
Route of Application: Intravenous
Exposure Time: (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Eye, ear. Effects on
Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 750 MG/KG
Route of Application: Oral
Exposure Time: (2-7D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Mouse
Dose: 600 MG/KG
Route of Application: Oral
Exposure Time: (1-7D PREG)
Result: Effects on Newborn: Stillbirth.
Species: Mouse
Dose: 400 MG/KG
Route of Application: Oral
Exposure Time: (12-15D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Maternal Effects: Parturition.
Species: Mouse
Dose: 124 MG/KG
Route of Application: Oral
Exposure Time: (7-10D PREG)
Result: Effects on Fertility: Abortion. Specific Developmental
Abnormalities: Eye, ear. Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 25 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
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Species: Dog
Dose: 390 MG/KG
Route of Application: Oral
Exposure Time: (8-20D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Musculoskeletal system.
Species: Monkey
Dose: 330 MG/KG
Route of Application: Oral
Exposure Time: (1-33D PREG)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Cat
Dose: 360 MG/KG
Route of Application: Oral
Exposure Time: (15-17D PREG)
Result: Effects on Fertility: Abortion. Specific Developmental
Abnormalities: Homeostasis
Species: Rabbit
Dose: 150 MG/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rabbit
Dose: 450 MG/KG
Route of Application: Oral
Exposure Time: (7-9D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Specific Developmental
Abnormalities: Urogenital system.
Species: Rabbit
Dose: 1200 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1-20D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Rabbit
Dose: 750 MG/KG
Route of Application: Intravenous
Exposure Time: (6-10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rabbit
Dose: 10 MG/KG
Route of Application: Intravenous
Exposure Time: (7D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mammal
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Dose: 1800 MG/KG
Route of Application: Oral
Exposure Time: (13-18D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants).
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Toxic solids, organic, n.o.s.
UN#: 2811
Class: 6.1
Packing Group: Packing Group III
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: Toxic solid, organic, n.o.s.
IATA UN Number: 2811
Hazard Class: 6.1
Packing Group: III
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: T
Indication of Danger: Toxic.
R: 46-61-21-25-62
Risk Statements: May cause heritable genetic damage. May cause
harm to the unborn child. Harmful in contact with skin. Toxic if
swallowed. Possible risk of impaired fertility.
S: 53-22-26-36/37/39-45
Safety Statements: Avoid exposure - obtain special instructions
before use. Do not breathe dust. In case of contact with eyes,
rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves, and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic.
Risk Statements: May cause harm to the unborn child. May cause
heritable genetic damage. Possible risk of impaired fertility.
Toxic if swallowed. Harmful in contact with skin.
Safety Statements: In case of accident or if you feel unwell,
seek medical advice immediately (show the label where possible).
Wear suitable protective clothing, gloves, and eye/face
protection. In case of contact with eyes, rinse immediately with
SIGMA - T144 www.sigma-aldrich.com Page 12
plenty of water and seek medical advice. Do not breathe dust.
US Statements: Calif. Prop. 65 developmental hazard.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause developmental toxicity.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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