FUJISAWA USA (LYPHOMED INC) -- VINBLASTINE SULFATE INJECTION ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 01/01/1994 MSDS Num: BTVLX LIIN: 00F036206 Product ID: VINBLASTINE SULFATE INJECTION MFN: 01 Responsible Party Cage: 24832 Name: FUJISAWA USA INC (LYPHOMED INC) Address: 3 PARKWAY NORTH City: DEERFIELD IL 60015-2548 Info Phone Number: 708-317-8800 Emergency Phone Number: 708-317-8202/800-727-7003 Preparer's Name: CHRISTINA J BARRINGTON Review Ind: Y Published: Y ======================================================= Preparer Co. when other than Responsible Party Co. ======================================================= Cage: 24832 Name: FUJISAWA USA INC (LYPHOMED INC) Address: 3 PARKWAY NORTH City: DEERFIELD IL 60015-2548 ======================================================= Contractor Summary ======================================================= Cage: 24832 Name: FUJISAWA USA INC (LYPHOMED INC) Address: 3 PARKWAY NORTH City: DEERFIELD IL 60015-2548 Phone: 800-727-7003/708-317-8800 Cage: 39832 Name: FUJISAWA USA, INC Address: 3 PKY N City: DEERFIELD IL 60015-2548 Phone: 847-317-1256 ======================================================= Ingredients ======================================================= Cas: 100-51-6 RTECS #: DN3150000 Name: BENZYL ALCOHOL % Wt: 0.9 ------------------------------ Cas: 7647-14-5 RTECS #: VZ4725000 Name: SODIUM CHLORIDE ------------------------------ Cas: 143-67-9 RTECS #: YY8400000 Name: VINBLASTINE SULFATE ------------------------------ Cas: 7732-18-5 RTECS #: ZC0110000 Name: WATER ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: ORAL LD50 (RAT): 305 MG/KG Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: IMMEDIATE EFFECTS: EYE, SKIN & RESPIRATORY IRRITATION, BONE MARROW SUPPRESSION, LOSS OF HAIR & NAUSEA MAY OCCUR. DIRECT EYE CONTACT CAN LEAD TO SEVERE IRRITATION & ULCERATION. EXTRAVASATION MAY CAUSE TISSUE IRRITATION & DAMAGE. DELAYED EFFECTS: HYPERSENSITIVITY REACTIONS MAY OCCUR RANGING FROM MILD TO SEVERE. Explanation Of Carcinogenicity: NONE Signs And Symptions Of Overexposure: IMMEDIATE EFFECTS: EYE, SKIN & RESPIRATORY IRRITATION, BONE MARROW SUPPRESSION, LOSS OF HAIR & NAUSEA MAY OCCUR. DIRECT EYE CONTACT CAN LEAD TO SEVERE IRRITATION & ULCERATION. EXTRAVASATION MAY CAUSE TISSUE IRRITATION & DAMAGE. DELAYED EFFECTS: HYPERSENSITIVITY REACTIONS MAY OCCUR RANGING FROM MILD TO SEVERE. Medical Cond Aggravated By Exposure: PRE-EXISTING SKIN & RESPIRATORY CONDITIONS. First Aid: INHALATION: MOVE TO FRESH AIR IMMEDIATELY. GIVE CPR IF REQUIRED. INGESTION: FLUSH MOUTH OUT W/WATER. SKIN: FLUSH W/WATER FOR 15 MINS. EYES: IMMEDIATELY FLUSH W/WATER FOR 15 MINS. OBTAIN MEDICAL ATTENT ION IN ALL CASES. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR RECOMMENDED PERSONAL PROTECTIVE EQUIPMENT. USE ABSORBENT TOWELS/BROOMS TO CLEAN UP. WIPE SURFACES CLEAN & WASH W/SOAP & WATER. Waste Disposal Methods: DISPOSE OF IN ACCORDANCE W/LOCAL, STATE & FEDERAL REGULATIONS. Handling And Storage Precautions: WHEN HANDLING PHARMACEUTICAL PRODUCTS, AVOID ALL CONTACT & INHALATION OF DUST, FUMES, MIST/VAPORS ASSOCIATED W/THE PRODUCT. ======================================================= Fire and Explosion Hazard Information ======================================================= Flash Point Method: CC Flash Point Text: >200F Extinguishing Media: WATER SPRAY, DRY CHEMICAL, CO2/FOAM Fire Fighting Procedures: WEAR SELF CONTAINED BREATHING APPARATUS & PROTECTIVE CLOTHING. Unusual Fire/Explosion Hazard: N/K . ======================================================= Control Measures ======================================================= Respiratory Protection: W/SATISFACTORY VENTILATION, NOT USUALLY REQUIRED. Ventilation: GENERAL ROOM USUALLY SATISFACTORY; LOCAL EXHAUST WHEN NECESSARY Protective Gloves: DISPOSABLE LATEX Eye Protection: SAFETY GLASSES/GOGGLES Other Protective Equipment: DISPOSABLE GARMENTS Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE REUSE. ======================================================= Physical/Chemical Properties ======================================================= PH: 3.5-5 Solubility in Water: COMPLETE Appearance and Odor: CLEAR, COLORLESS, ODORLESS SOLUTION. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Stability Condition To Avoid: EXCESSIVE LIGHT/HEAT Hazardous Decomposition Products: SMOKE, TOXIC FUMES OF SULFUR OXIDE & NITROGEN OXIDE Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= ======================================================= Ecological Information ======================================================= ======================================================= MSDS Transport Information ======================================================= ======================================================= Regulatory Information ======================================================= ======================================================= Other Information ======================================================= ======================================================= HAZCOM Label ======================================================= Product ID: VINBLASTINE SULFATE INJECTION Cage: 24832 Company Name: FUJISAWA USA INC (LYPHOMED INC) Street: 3 PARKWAY NORTH City: DEERFIELD IL Zipcode: 60015-2548 Health Emergency Phone: 708-317-8202/800-727-7003 Date Of Label Review: 08/18/1994 Status Code: C Label Date: 08/18/1994 Origination Code: Z ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.