GLAXO -- RANTIDINE HYDROCHLORIDE - ZANTAC - AH19065 - RANTIDINE INJECTION,USPGLAXO -- RANTIDINE HYDROCHLORIDE - ZANTAC - AH19065 - RANTIDINE INJECTION,USP MATERIAL SAFETY DATA SHEET GLAXONSN: 6505012060278 Manufacturer's CAGE: 34006 Part No. Indicator: A Part Number/Trade Name: RANTIDINE HYDROCHLORIDE - ZANTAC - AH19065 =========================================================================== General Information =========================================================================== Item Name: RANTIDINE INJECTION,USP Company's Name: GLAXO INC Company's Street: 5 MOORE DR Company's City: RESEARCH TRIANGLE PARK Company's State: NC Company's Country: US Company's Zip Code: 27709 Company's Emerg Ph #: 919-248-2100/2700 Company's Info Ph #: 919-248-2354 Record No. For Safety Entry: 001 Tot Safety Entries This Stk#: 001 Status: SE Date MSDS Prepared: 01OCT88 Safety Data Review Date: 31DEC94 Supply Item Manager: CX MSDS Serial Number: BWMHD Specification Number: NONE Spec Type, Grade, Class: NONE Hazard Characteristic Code: N1 Unit Of Issue: VI Unit Of Issue Container Qty: 10 ML Type Of Container: VIAL Net Unit Weight: UNKNOWN NRC/State License Number: NONE Net Propellant Weight-Ammo: NONE =========================================================================== Ingredients/Identity Information =========================================================================== Proprietary: NO Ingredient: RANTIDINE HYDROCHLORIDE (ZANTAC) Ingredient Sequence Number: 01 Percent: 100 NIOSH (RTECS) Number: KM6557000 OSHA PEL: NOT ESTABLISHED ACGIH TLV: NOT ESTABLISHED Other Recommended Limit: 0.05 MG/M3 MFR. =========================================================================== Physical/Chemical Characteristics =========================================================================== Appearance And Odor: OFF-WHITE TO PALE YELLOW COLORED POWDER, CHARACTERISTIC SULFUR-LIKE ODOR. Boiling Point: N/A Melting Point: 272F,133C Vapor Pressure (MM Hg/70 F): N/A Vapor Density (Air=1): N/A Specific Gravity: N/A Decomposition Temperature: UNKNOWN Evaporation Rate And Ref: N/A Solubility In Water: VERY SOLUBLE Viscosity: UNKNOWN Corrosion Rate (IPY): UNKNOWN Autoignition Temperature: N/A =========================================================================== Fire and Explosion Hazard Data =========================================================================== Flash Point: N/A Lower Explosive Limit: UNKNOWN Upper Explosive Limit: UNKNOWN Extinguishing Media: WATER SPRAY, FOAM, MULTI-PURPOSE DRY CHEMICAL Special Fire Fighting Proc: WEAR FULL PROTECTIVE CLOTHING & USE SELF- CONTAINED BREATHING APPARATUS (SCBA). Unusual Fire And Expl Hazrds: AS WITH ANY ORGANIC DUST, THERE IS POTENTIAL FOR EXPLOSION WHEN SUSPENDED IN AIR IN HIGH CONCENTRATIONS. =========================================================================== Reactivity Data =========================================================================== Stability: YES Cond To Avoid (Stability): EXTREME HEAT, MATERIAL DECOMPOSES AT 300 DEGREES F. Materials To Avoid: NO KNOWN INCOMPATIBILITIES Hazardous Decomp Products: THERMAL DECOMPOSITION PRODUCTS INCLUDE TOXIC AND CORROSIVE VAPORS OF CHLORIDES AND OXIDES OF NITROGEN AND SULFUR. Hazardous Poly Occur: NO Conditions To Avoid (Poly): N/A =========================================================================== Health Hazard Data =========================================================================== LD50-LC50 Mixture: LD50 (ORAL RAT) IS UNKNOWN Route Of Entry - Inhalation: YES Route Of Entry - Skin: YES Route Of Entry - Ingestion: YES Health Haz Acute And Chronic: ACUTE-IRRITATION. MAY LEAD TO SENSITIZATION. CHRONIC-CHRONIC OVEREXPOSURE MAY CAUSE SKIN RASH, NASAL SYMPTOMS AND SHORTNESS OF BREATH W/WHEEZING. Carcinogenicity - NTP: NO Carcinogenicity - IARC: NO Carcinogenicity - OSHA: NO Explanation Carcinogenicity: THERE IS NO PUBLISHED EVIDENCE TO SHOW THAT THE COMPOUND IS CARCINOGENIC, MUTAGENIC OR TERATOGENIC. RESPIRATORY IRRITATION, NASAL CONGESTION, RUNNY NOSE, SHORTNESS OF BREATH, WHEEZING. EYE:IRRITATION. INGESTED:HEADACHE, REVERSABLE INFLAMMATION OF LIVER ACCOMPANIED BY JAUNDICE. Med Cond Aggravated By Exp: MFR GAVE NO INFORMATION ON MSDS.. Emergency/First Aid Proc: IF ANY IRRITATION PERSISTS OR IS SEVERE, SEE A DOCTOR. EYE:FLUSH W/WATER 15 MIN, HOLD LIDS OPEN. SKIN:REMOVE CONTAMINATED CLOTHING AND WASH WITH SOAP & WATER. INHALED:REMOVE TO FRESH AIR. RESTORE/AID BREATHING AS NEEDED. INGESTED:IMMEDIATELY GIVE LARGE QUANTITIES OF WATER AND ENCOURAGE VOMITING. GET IMMEDIATE MEDICAL ATTENTION. =========================================================================== Precautions for Safe Handling and Use =========================================================================== Steps If Matl Released/Spill: WEAR PROTECTIVE EQUIPMENT. COLLECT SPILLAGE BY CAREFULLY SWEEPING OR VACUUMING W/HEPA FILTERED VACUUM AND PLACE IN LABELED, SEALED CONTAINER FOR REUSE OR DISPOSAL. WASH AREA W/WATER AFTER VACUUMING. Neutralizing Agent: MFR GAVE NO INFORMATION ON MSDS. Waste Disposal Method: INCINERATE AT AN APPROVED FACILITY I/A/W FEDERAL, STATE & LOCAL REGULATIONS. Precautions-Handling/Storing: USE STORAGE PRACTICES THAT WILL MINIMIZE GENERATION OF DUST. Other Precautions: NONE =========================================================================== Control Measures =========================================================================== Respiratory Protection: RESPIRATORY PROTECTIVE EQUIPMENT SHOULD BE WORN WHEN EXPOSED TO AIRBORN DUST LEVELS THAT EXCEED THE ESTIMATED SAFE WORKING LEVEL. MAKE RESPIRATOR SELECTION PER NIOSH, ANSI Z88.2 & RESPIRATORY EQUIPMENT MANUFACTURER RECOMMENDATIONS. Ventilation: PROVIDE LOCAL EXHAUST VENTILATION AT THE SOURCE OF GENERATION OF DUST. Protective Gloves: PROTECTIVE GLOVES Eye Protection: EYE PROTECTION FOR HIGH DUST LEVELS Other Protective Equipment: FOR LOW DUST LEVELS USE A PROTECTIVE OUTER GARMENT. FOR HIGH LEVELS USE FULL BODY PROTECTION. AVOID ALL SKIN CONTACT. Work Hygienic Practices: ENSURE THAT CONTAMINATED CLOTHING & EQUIPMENT ARE PROPERLY CLEANED AFTER USE. CHANGE CLOTHES AND SHOWER AFTER WORK. Suppl. Safety & Health Data: NONE =========================================================================== Transportation Data =========================================================================== Trans Data Review Date: 94365 DOT PSN Code: ZZZ DOT Proper Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION IMO PSN Code: ZZZ IMO Proper Shipping Name: NOT REGULATED FOR THIS MODE OF TRANSPORTATION IATA PSN Code: ZZZ IATA Proper Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION AFI PSN Code: ZZZ AFI Prop. Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION Additional Trans Data: MSDS IS FOR A POWDER WHILE THE UNIT OF ISSUE IS FOR AN INJECTIBLE SOLUTION. =========================================================================== Disposal Data =========================================================================== =========================================================================== Label Data =========================================================================== Label Required: YES Technical Review Date: 21FEB95 Label Status: F Common Name: ZANTAC Signal Word: CAUTION! Acute Health Hazard-Slight: X Contact Hazard-Slight: X Fire Hazard-None: X Reactivity Hazard-None: X Special Hazard Precautions: CHRONIC OVEREXPO MAY CAUSE SKIN RASH,NASAL SYMPTOMS,SHORTNESS OF BREATH W/WHEEZING.SKIN:IRRIT,RASH.REPEATED CONTACT IRRIT MUC MEMB.EYE:IRRIT.INGEST:HEAD(SOMETIMES SEVERE),REVERSIBLE INFLAMM OF LIVER ACCOMPANIED BY JAUNDICE.USE STORAGE PRACTICES THAT MINIMIZE GENERATION OF DUST.TARGET ORGANS:EYES/SKIN/RESP TRACT.1STAID:EYES:FLUSH W/ LOTS OF WATER.GET MED ATTN.SKIN:REMOVE CONTAMIN CLOTHING.WASH SKIN W/SOAP/ WATER.INHAL:REMOVE TO FRESH AIR.BREATH DIFFI/CEASES GIVE OXYG/CPR.GET MED ATTN FOR ANY RESP SYMPTOMS.INGEST:RINSE MOUTH.GIVE LOTS OF WATER.ENCOURAGE VOMIT.GET MED ATTN. Protect Eye: Y Protect Skin: Y Protect Respiratory: Y Label Name: GLAXO INC Label Street: 5 MOORE DR Label City: RESEARCH TRIANGLE PARK Label State: NC Label Zip Code: 27709 Label Country: US Label Emergency Number: 919-248-2100/2700