ZEOCIN Safety Data Sheet Date: 10.03.03 Date of printing: 10.05.03 Page 1 of 2 1. Name of substance/preparation and company 1.1 Commercial product: Zeocin Cat.-No.: ant-zn-1, ant-zn-5, ant-zn-1p, ant-zn-5p 1.2 Company: CAYLA SAS- InvivoGen Corp. 5 rue Jean Rodier BP 4437 31 405 Toulouse Cedex 04 France Tel. ++33 (0)5 62 71 69 39 Information obtainable from: ++33 (0)5 62 71 69 39 This product is for laboratory use only and is not intended for human or animal diagnostics, therapeutic or clinical uses 2. Composition/Information on constituents The following list shows components of this product classified as hazardous based on physical properties and health effects Phleomycin, not classified as hazardous component CAS-No.: 11006-33-0 Molecular formula (phleomycin D1 main product):C55H85N20O21S2Cu. HCL Molecular weight (phleomycin D1 main product): 1525 . 3. Hazards identification Warnings: The usual precautions taken when handling chemicals should be observed. Danger! NOCIF IN CASE OF INGESTIONt! toxic if swallowed. May cause organ failure or death even at low dose toxic if absorbed toxic by inhalation Potential health effects: - Eyes: May cause irritation. -Skin: Can cause moderate skin irritation,. Not likely to cause permanent damage. - Inhalation: Can cause moderate respiratory irritation, nausea and headhache. -Ingestion: Irritating to mouth, throat and stomach. toxic if swallowed. May cause target organ failure. Chronic effects: - possible mutagen - target organs: lung, liver Target organ Data: - see RTCES n° SY0525000 for complete information 4. First aid measures First aid: Eye contact: Wash immediately eyes with plenty of water for at least 15 minutes. Get medical attention; Skin contact: Wash off with water and soap, remove contaminated clothes. Get medical attention Ingestion: give plenty of water if conscious. If vomiting occurs naturally, wash mouth out. Be prepared to induce vomiting upon advice. Obtain medical attention if symptoms develop. Inhalation: Remove victim to fresh air, if malaise develops go to a physician Instructions for symptomatic treatment by a physician: Treat symptomatically 5. Fire-fighting masures Flash point Degree : Not available Upper flammable limit %: Not available Lower flammable limit %: Not available Autoignition temperature degree: Not available Extinguishing media: Use alcohol or resistant foam, carbon dioxide or dry chemical fighting fire. Hazardous combustion products: toxic fumes of carbon dioxide, carbon monoxide, nitrogen oxides, dense smoke 6. Accidental release measures Refer to section 8 for personal protection equipment recommendations. After spillage: Sweep up spilled substance carefully. Absorbent material: suitable absorbent material like . Damage limitation: Special measures to limit damage are to be taken. 7. Handling and storage Storage of some material could be regulated by federal, state, and/or local laws. 7.1 Handling: toxic material. Avoid contacting and breathing the material. Use only in a ventilated area. 7.2 Storage: Store in a cool place at ambient pressure, and in suitable storage area. Hydrophilic material; Keep tightly closed when not in use ZEOCIN Safety Data Sheet <~ Date: 10.03.03 Date of printing: 10.05-03 Page 2 of 2 8. Exposure controls- personal protection Engineering controls : local exhaust ventilation or other engineering controls are normally required when handling or using this product to avoid overexposure. Respiratory protection: wear protective respiratory mask Eye protection: use protective glasses Hand protection: wear protective compatible resistant gloves Hygiene: Wash hands before breaks and at the end of the work. 9. Physical and chemical properties Physical state : powder Colour: blue Odour: none PH: N.A. Boiling point: no data Melting point: N.A. Solubility in water: soluble Density : Viscosity: not determined 10. Stability and reactivity Stability : stable under normal conditions Conditions to avoid : heat, strong oxidising agents Reactions: Not known when used appropriately. Hazardous decomposition products : Carbon monoxide, Carbon dioxide. Nitrogen oxides Hazardous polymerisation: will not occur 11. Toxicological information LD50 oral/ingestion not known LD50 dermal not known LD50 inhalation/respiratory not known Toxicological information: Intoxication has so far not become known. See actual entry in RTECS for complete toxicological informations. 12. Ecological information Hazards: Substance can be slightly hazardous to water and ground water even if no ecological information is available Environmental fate: Bioconcentration is not expected to occur 13. Disposal considerations Regulatory information: not applicable Waste disposal route: Can be sent to an incineration plant in accordance with all state, federal, local regulations. Clean up and dispose of waste in accordance with all state, federal, local regulations. 14. Transport information UN number ICAO/IATA: Proper Shipping Name: Zeocin Notes: product non subject to current regulations for transportation of hazardous goods (GGVS/ADR, GGVE/RID, IMDG, IATA/ICAO). Hazard class No hazardous component, class Xn 15. Regulatory Information Notes: R22 Nocif in case of ingestion S24/26 Avoid contact with skin and eyes S36/37/39 Wear protective clothing, respiratory mask, gloves and eyes protection 16. Other information The information herein is believed to be correct as of the date hereof, but is provided without warranty of any kind. The recipient of our product is responsible for ensuring that, where applicable, existing laws and guidelines are observed.