WYETH-AYERST (DIVISION OF AMERICAN HOME PRODUCTS) -- 08453 ZOSYN -- 6505-00F043803 ===================== Product Identification ===================== Product ID:08453 ZOSYN MSDS Date:11/02/1993 FSC:6505 NIIN:00F043803 MSDS Number: CDFWD === Responsible Party === Company Name:WYETH-AYERST (DIVISION OF AMERICAN HOME PRODUCTS) Address:150 A1 RADNOR CHESTER RD City:SAINT DAVIDS State:PA ZIP:19087-5000 Country:US Info Phone Num:610-902-5171/800-666-7248 Emergency Phone Num:610-902-5171/800-666-7248 CAGE:GO449 === Contractor Identification === Company Name:AMERICAN HOME PRODUCTS CORP,WYETH-AYERST LABORATOR Address:555 E LANCASTER AVE City:ST. DAVIDS State:PA ZIP:19087 Country:US Phone:215-971-4505 CAGE:04543 Company Name:WYETH-AYERST (DIVISION OF AMERICAN HOME PRODUCTS) Address:150 A1 RADNOR CHESTER RD City:SAINT DAVIDS State:PA ZIP:19087-5000 Country:US Phone:610-902-5171/800-666-7248 CAGE:GO449 ============= Composition/Information on Ingredients ============= Ingred Name:TAZOBACTAM, SODIUM SALT *96-4* CAS:89785-84-2 RTECS #:XI0191500 Ingred Name:SODIUM BICARBONATE CAS:144-55-8 RTECS #:VZ0950000 Fraction by Wt: 2.5-5% Ingred Name:PIPERACILLIN, T 1220 CAS:61477-96-1 RTECS #:XH8952200 Ingred Name:PIPERACILLIN SODIUM, PENTCILLIN *96-4* CAS:59703-84-3 RTECS #:XI0180000 Ingred Name:TAZOBACTAM CAS:89786-04-9 ===================== Hazards Identification ===================== LD50 LC50 Mixture:ORAL LD50(RATS): 4220 MG/KG (SEE SUPP) Routes of Entry: Inhalation:YES Skin:NO Ingestion:YES Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO Health Hazards Acute and Chronic:EYES: MAY CAUSE IRRITATION. INHALATION: IRRITATION OF THE RESPIRATORY TRACT. INGESTION: GASTROINTESTINAL SYMPTOMS MAY OCCUR. ALSO SKIN REACTIONS, SYSTEMIC ALLERGIC REACTIONS; LIVER FUNCTION ABNORMALIT IES. Explanation of Carcinogenicity:NONE Effects of Overexposure:IRRITATION, DIARRHEA, NAUSEA, VOMITING, RASH, PRURITUS, SEVERE ITCHING, ERYTHEMA (REDNESS) Medical Cond Aggravated by Exposure:PERSONS ALLERGIC TO PENICILLIN/CEPHALOSPORIN-TYPE ANTIBIOTICS/OTHER B-LACTAMASE INHIBITORS. ======================= First Aid Measures ======================= First Aid:EYES: IMMEDIATELY FLUSH W/PLENTY OF COOL, LOW-PRESSURE WATER FOR 20 MINS. SKIN: PROMPTLY WASH W/SOAP & COOL RUNNING WATER. INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXGYEN IF NECESSARY. INGESTION: DON 'T INDUCE VOMITING EXCEPT AS DIRECTED BY MEDICAL PERSONNEL. NEVER GIVE ANYTHING BY MOUTH IF UNCONSCIOUS. NEVER INDUCE VOMITING IF UNCONSCIOUS. OBTAIN MEDICAL ATTENTION IN ALL CASES. ===================== Fire Fighting Measures ===================== Unusual Fire/Explosion Hazard:WHEN HEATED TO DECOMPOSITION, POSSIBLY EMITS VERY TOXIC FUMES OF SULFUR CONTAINING COMPOUNDS. ================== Accidental Release Measures ================== Spill Release Procedures:WEAR DISPOSABLE COVERALLS, RUBBER GLOVES & AN APPROVED FULL-FACE, AIR PURIFYING RESPIRATOR W/HIGH-EFFICIENCY CARTRIDGES/A SELF CONTAINED /SUPPLIED-AIR RESPIRATOR, CONTAIN & COLLECT MATERIALS. ====================== Handling and Storage ====================== Handling and Storage Precautions:VIALS CONTAINING LYOPHILIZED PIPERACILLIN/TAZOBACTAM SHOULD BE STORED AT CONTROLLED ROOM TEMP 59-86F & USED W/IN 24 HR AFTER STORAGE AT ROOM TEMP. Other Precautions:FOR LONGER TERM STORAGE, RECONSTITUTED VIALS SHOULD BE STORED UNDER REFRIGERATION 36-46F & IF NOT USED, DISCARDED AFTER 7 DAYS. MINIMIZE EXCESS HANDLING. KEEP CONTAINER CLOSED WHEN NOT IN USE. ============= Exposure Controls/Personal Protection ============= Respiratory Protection:WHEN ENGINEERING CONTROLS AREN'T ADEQUATE TO CONTAIN DUST/MIST, WEAR AN APPROVED AIR-PURIFYING RESPIRATOR W/HIGH-EFFICIENCY CARTRIDGES/A SUPPLIED-AIR RESPIRATOR. Ventilation:USE CLOSED-SYSTEM HANDLING, LABORATORY BENCH HOOD/LOCAL EXHAUST VENTILATION TO CONTROL DUST/MIST. Protective Gloves:RUBBER Eye Protection:REQUIRED Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE REUSE. DESTROY CONTAMINATED LEATHER ITEMS. Supplemental Safety and Health INFORMATION FOR ORAL LD50 IS FOR SODIUM BICARBONATE. ================== Physical/Chemical Properties ================== Melt/Freeze Pt:M.P/F.P Text:311F Spec Gravity:1.0512 pH:6.8 Solubility in Water:MODERATE Appearance and Odor:WHITE TO OFF-WHITE SUSPENSION Percent Volatiles by Volume:80 ================= Stability and Reactivity Data ================= Stability Indicator/Materials to Avoid:YES STRONG OXIDIZERS & STRONG BASES Hazardous Decomposition Products:HYDROGEN SULFIDE, SULFUR DIOXIDE/OTHER SULFUR CONTAINING COMPOUNDS ==================== Disposal Considerations ==================== Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE & FEDERAL REGULATIONS. INCINERATION IS RECOMMENDED. Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever, expressly or implied, warrants this information to be accurate and disclaims all liability for its use. Any person utilizing this document should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation.