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Material Safety Data Sheet
Printing date 01/17/2008 Reviewed on 01/16/2008
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1 Identification of substance:
· Product details:
· Trade name: Zymogram Sample Buffer
· Catalog or product number: 1610764
· Application of the substance / the preparation Laboratory chemicals
· Manufacturer/Supplier:
Bio-Rad Laboratories, Life Science Group
2000 Alfred Nobel Drive
Hercules, California 94547 (510)741-1000
· Information department: Technical services, customer support.
· Emergency information:
1(800)424-9300 Use only in the event of a CHEMICAL EMERGENCY involving a SPILL, LEAK, FIRE, EXPLOSION or ACCIDENT.
510-741-1000
2 Composition/Information on components:
· Chemical characterization
· Description: Mixture of the substances listed below with non-hazardous additions.
· Listing of dangerous and non-hazardous components:
CAS: 7732-18-5
EINECS: 231-791-2
RTECS: ZC 0110000
water 50-100%
CAS: 56-81-5
EINECS: 200-289-5
RTECS: MA 8050000
glycerol 20-35%
CAS: 151-21-3
EINECS: 205-788-1
RTECS: WT 1050000
sodium dodecyl sulphate Xn, Xi; R 20/22-36/37/38-42 2.5-5%
· Additional information For the wording of the listed risk phrases refer to section 15.
3 Hazards identification
· Emergency overview:
Sensitizer by inhalation.
Irritant to respiratory system and skin.
Xn Harmful
· Routes of exposure: Inhalation
· Information pertaining to particular dangers for man and environment
The product has to be labelled due to the calculation procedure of the "General Classification guideline for preparations of the EU" in
the latest valid version.
R 42 May cause sensitization by inhalation.
· Classification system
The classification was made according to the latest editions of the EU-lists, and expanded upon from company and literature data.
4 First aid measures
· After inhalation Supply fresh air; consult doctor in case of complaints.
· After skin contact Generally the product does not irritate the skin.
· After eye contact Rinse opened eye for several minutes under running water. Then consult a doctor.
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Material Safety Data Sheet
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Trade name: Zymogram Sample Buffer
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· After swallowing Induce vomiting and call for medical help.
5 Fire fighting measures
· Suitable extinguishing agents Use fire fighting measures that suit the environment.
· Protective equipment: No special measures required.
6 Accidental release measures
· Person-related safety precautions: Not required
· Measures for environmental protection:
Dilute with plenty of water.
Do not allow to enter sewers/ surface or ground water.
· Measures for cleaning/collecting:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to item 13.
7 Handling and storage
· Handling
· Information for safe handling:
Ensure good ventilation/exhaustion at the workplace.
No special precautions are necessary if used correctly.
· Information about protection against explosions and fires: No special measures required.
· Storage
· Requirements to be met by storerooms and receptacles: According to product specification
· Information about storage in one common storage facility: Not required.
· Further information about storage conditions: None.
* 8 Exposure controls and personal protection
· Additional information about design of technical systems: No further data; see item 7.
· Components with limit values that require monitoring at the workplace:
56-81-5 glycerol
PEL ()
TLV ()
15* 5** mg/m³
*total dust **respirable fraction
10 ppm
· Additional information: The lists that were valid during the creation were used as basis.
· Personal protective equipment
· General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Wash hands before breaks and at the end of work.
· Breathing equipment:
In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective
device that is independent of circulating air.
· Protection of hands: Protective gloves.
· Material of gloves Synthetic gloves
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Material Safety Data Sheet
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Trade name: Zymogram Sample Buffer
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· Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
· Eye protection: Safety glasses
* 9 Physical and chemical properties:
· General Information
Form: liquid
Color: According to product specification
Odor: Odorless
· Change in condition
Melting point/Melting range: undetermined
Boiling point/Boiling range: 100°C
· Flash point: > 100°C
· Ignition temperature: 400°C
· Auto igniting: Product is not selfigniting.
· Danger of explosion: Product does not present an explosion hazard.
· Explosion limits:
Lower: 0.9 Vol %
· Vapor pressure at 20°C: 23 hPa
· Density: Not determined
· Solubility in / Miscibility with
Water: Fully miscible
· Solvent content:
· Organic solvents: 26.3 %
· Water: 68.7 %
· Solids content: 5.0 %
10 Stability and reactivity
· Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
· Dangerous reactions No dangerous reactions known
· Dangerous products of decomposition: No dangerous decomposition products known
11 Toxicological information
· Acute toxicity:
· LD/LC50 values for hazardous components per OSHA criteria:
151-21-3 sodium dodecyl sulphate
Oral LD50 1288 mg/kg (rat)
Dermal LD50 580 mg/kg (rab)
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Material Safety Data Sheet
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Trade name: Zymogram Sample Buffer
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· Primary irritant effect:
· on the skin: No irritant effect.
· on the eye: No irritant effect.
· Sensitization: Sensitization possible through inhalation.
· Additional toxicological information:
The product shows the following dangers according to the calculation method of the General EU Classification Guidelines for
Preparations as issued in the latest version:
Harmful
· Target organs: Respiratory tract.
12 Ecological information:
· General notes:
Water hazard class 1 (German Regulation) (Self-assessment): slightly hazardous for water.
Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system.
13 Disposal considerations
· Product:
· Recommendation
Hand over to hazardous waste disposers.
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
· Uncleaned packagings:
· Recommendation: Disposal must be made according to official regulations.
· Recommended cleansing agent: Water, if necessary with cleansing agents.
14 Transport information
· DOT regulations:
· Hazard class: -
· Land transport ADR/RID (cross-border)
· ADR/RID class: -
· Maritime transport IMDG:
· IMDG Class: -
· Marine pollutant: No
· Air transport ICAO-TI and IATA-DGR:
· ICAO/IATA Class: -
* 15 Regulations
· SARA (Superfund Amendents and Reauthorization Act of 1986 - USA)
· Section 302/304 (40CFR355.30 / 40CFR355.40):
None of the ingredients is listed.
· Section 313 (40CFR372.65):
None of the ingredients is listed.
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Material Safety Data Sheet
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Trade name: Zymogram Sample Buffer
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· TSCA (Toxic Substances Control Act):
All ingredients are listed.
· Cancerogenity categories
· EPA (Environmental Protection Agency)
None of the ingredients is listed.
· IARC (International Agency for Research on Cancer)
None of the ingredients is listed.
· NTP (National Toxicology Program)
None of the ingredients is listed.
· TLV (Threshold Limit Value established by ACGIH)
None of the ingredients is listed.
· MAK (German Maximum Workplace Concentration)
None of the ingredients is listed.
· NIOSH-Ca (National Institute for Occupational Safety and Health)
None of the ingredients is listed.
· OSHA-Ca (Occupational Safety & Health Administration)
None of the ingredients is listed.
· Markings according to EU guidelines:
The product has been classified and marked in accordance with EU Directives / Ordinance on Hazardous Materials
· Code letter and hazard designation of product:
Xn Harmful
· Hazard-determining components of labelling:
sodium dodecyl sulphate
· Risk phrases:
42 May cause sensitization by inhalation.
· Safety phrases:
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36 Wear suitable protective clothing.
45 In case of accident or if you feel unwell, seek medical advice immediately.
60 This material and its container must be disposed of as hazardous waste.
· National regulations
Class Share in %
NK 20-35
· Water hazard class: Water hazard class 1 (Self-assessment): slightly hazardous for water.
16 Other information:
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and
shall not establish a legally valid contractual relationship.
· Department issuing MSDS: Environmental Health and Safety.
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Material Safety Data Sheet
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Trade name: Zymogram Sample Buffer
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· Contact:
Life Science Group, Environmental Health and Safety, 2000 Alfred Nobel Drive, Hercules, California, 94547: 1(510) 741-1000
Diagnostic Group, Environmental Health and Safety, 4000 Alfred Nobel Drive, Hercules, California, 94547: 1(510) 724-7000
· * Data compared to the previous version altered.
USA