======================================================= MSDS Safety Information ======================================================= NAME: MUCICARMINE STAIN ======================================================= SAFETY DATA SHEET 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING VENTANA MEDICAL SYSTEMS, INC. 1910 E. Innovation Park Drive Tucson, Arizona 85755 U.S.A. +1 (520) 887-2155 (800) 227-2155 (U.S.) EC REP Roche Diagnostics GmbH Roche Diagnostics Australia Pty. Ltd Sandhofer Strasse 116 31 Victoria Avenue D-68305 Mannheim Castle Hill, NSW, 2154 Germany Australia Phone: 61-2-9860-2329 Fax: 61-2-9860-2133 Emergency Phone Number: 61-2-9759-4301 SDS NUMBER: 00232132 SUBSTANCE: Mucicarmine Stain PRODUCT NUMBER(S): 1522400 PRODUCT USE: clinical/research CREATION DATE: Sep 06 2006 REVISION DATE: Mar 05 2009 2. HAZARDS IDENTIFICATION NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=3 REACTIVITY=0 EC CLASSIFICATION: F Highly flammable RISK PHRASES: R 11 Highly flammable. EMERGENCY OVERVIEW: COLOUR: purple PHYSICAL FORM: liquid ODOUR: alcohol odour MAJOR HEALTH HAZARDS: respiratory tract irritation, skin irritation, eye irritation, liver damage, central nervous system depression PHYSICAL HAZARDS: Flammable liquid and vapour. Vapour may cause flash fire. POTENTIAL HEALTH EFFECTS: INHALATION: SHORT TERM EXPOSURE: irritation, difficulty breathing, headache, drowsiness, dizziness, loss of coordination LONG TERM EXPOSURE: irritation, nausea, headache, drowsiness, fatigue, dizziness, disorientation, tremours SKIN CONTACT: SHORT TERM EXPOSURE: irritation LONG TERM EXPOSURE: irritation EYE CONTACT: SHORT TERM EXPOSURE: irritation LONG TERM EXPOSURE: eye damage INGESTION: SHORT TERM EXPOSURE: changes in body temperature, changes in blood pressure, nausea, vomiting, difficulty breathing, irregular heartbeat, drowsiness, disorientation, difficulty speaking, mood swings, loss of coordination, visual disturbances, dilated pupils, convulsions, coma LONG TERM EXPOSURE: diarrhoea, loss of appetite, weight loss, irregular heartbeat, disorientation, pain in extremities, tremours, visual disturbances, heart damage, kidney damage, liver damage, birth defects, brain damage 3. COMPOSITION, INFORMATION ON INGREDIENTS COMPONENT: Ethanol CAS NUMBER: 64-17-5 EC NUMBER (EINECS): 200-578-6 PERCENTAGE: Proprietary EC CLASSIFICATION: F RISK PHRASES: 11 COMPONENT: Non-hazardous CAS NUMBER: Not assigned. EC NUMBER: Not assigned. PERCENTAGE: >1 EC CLASSIFICATION: No classification assigned. 4. FIRST AID MEASURES INHALATION: If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. If breathing is difficult, oxygen should be administered by qualified personnel. Get immediate medical attention. SKIN CONTACT: Wash contaminated areas with soap and water. Thoroughly clean and dry contaminated clothing before reuse. Get medical attention, if needed. EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. INGESTION: If a large amount is swallowed, get medical attention. NOTE TO PHYSICIAN: For inhalation, consider oxygen. 5. FIRE FIGHTING MEASURES FIRE AND EXPLOSION HAZARDS: Severe fire hazard. Vapour/air mixtures are explosive. The vapour is heavier than air. Vapours or gases may ignite at distant ignition sources and flash back. EXTINGUISHING MEDIA: alcohol resistant foam, carbon dioxide, regular dry chemical, water FIRE FIGHTING: Move container from fire area if it can be done without risk. Cool containers with water spray until well after the fire is out. Flood with fine water spray. Do not scatter spilled material with highpressure water streams. Avoid inhalation of material or combustion by-products. SENSITIVITY TO MECHANICAL IMPACT: Not sensitive SENSITIVITY TO STATIC DISCHARGE: Yes FLASH POINT: 55 F (13 C) (TCC, Ethanol) LOWER FLAMMABLE LIMIT: 3.3% (Ethanol) UPPER FLAMMABLE LIMIT: 19% (Ethanol) AUTOIGNITION: 685 F (363 C) (Ethanol) FLAMMABILITY CLASS (OSHA): IB HAZARDOUS COMBUSTION PRODUCTS: Thermal decomposition or combustion products: oxides of carbon 6. ACCIDENTAL RELEASE MEASURES OCCUPATIONAL RELEASE: Avoid heat, flames, sparks and other sources of ignition. Remove sources of ignition. Stop leak if possible without personal risk. Reduce vapours with water spray. Small spills: Absorb with sand or other noncombustible material. Collect spilled material in appropriate container for disposal. 7. HANDLING AND STORAGE STORAGE: Store and handle in accordance with all current regulations and standards. Store between 2 C and 8 C. Earthing and bonding required. See original container for storage recommendations. Keep separated from incompatible substances. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION EXPOSURE LIMITS: Ethanol: Ethyl alcohol (Ethanol): 1000 ppm (1900 mg/m3) OSHA TWA 1000 ppm ACGIH TWA 1000 ppm (1900 mg/m3) NIOSH recommended TWA 10 hour(s) 960 mg/m3 (500 ml/m3) DFG MAK (peak limitation category - II, with excursion factor of 2) 1000 ppm (1920 mg/m3) UK WEL TWA VENTILATION: Provide adequate ventilation. Ensure compliance with applicable exposure limits. EYE PROTECTION: Safety glasses or goggles are recommended when there is a potential for eye contact. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. CLOTHING: Lab coat or apron. GLOVES: Wear appropriate chemical resistant gloves. PROTECTIVE MATERIAL TYPES: latex, nitrile, vinyl RESPIRATOR: No respirator is required under normal conditions of use. 9. PHYSICAL AND CHEMICAL PROPERTIES PHYSICAL STATE: liquid APPEARANCE: opaque COLOUR: purple ODOUR: alcohol odour BOILING POINT: 173 F (78.3 C) (Ethanol) FREEZING POINT: Not available VAPOUR PRESSURE: Not available VAPOUR DENSITY (air=1): 1.59 (Ethanol) SPECIFIC GRAVITY: Not available WATER SOLUBILITY: miscible PH: acidic VOLATILITY: Not available ODOUR THRESHOLD: Not available EVAPORATION RATE: Not available COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available 10. STABILITY AND REACTIVITY REACTIVITY: Stable at normal temperatures and pressure. CONDITIONS TO AVOID: Avoid heat, flames, sparks and other sources of ignition. Containers may rupture or explode if exposed to heat. INCOMPATIBILITIES: oxidising materials, peroxides, acids, halo carbons, metals, metal salts, halogens, metal oxides, bases, combustible materials HAZARDOUS DECOMPOSITION: Thermal decomposition or combustion products: oxides of carbon POLYMERISATION: Will not polymerise. 11. TOXICOLOGICAL INFORMATION Ethanol: IRRITATION DATA: 400 mg open skin-rabbit mild; 20 mg/24 hour(s) skin-rabbit moderate; 500 mg eyesrabbit severe; 500 mg/24 hour(s) eyes-rabbit mild; 100 mg/4 second(s) rinsed eyes-rabbit moderate TOXICITY DATA: 20000 ppm/10 hour(s) inhalation-rat LC50; 7 gm/kg oral-rat LD50 CARCINOGEN STATUS: NTP: Known Human Carcinogen (Alcoholic beverages); IARC: Human Sufficient Evidence, Animal Sufficient Evidence, Group 1 (Alcoholic beverages), (Ethanol in alcoholic beverages); ACGIH: A4 -Not Classifiable as a Human Carcinogen LOCAL EFFECTS: Irritant: inhalation, skin, eye ACUTE TOXICITY LEVEL: Slightly toxic: inhalation, ingestion TARGET ORGANS: central nervous system, liver MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: central nervous system disorders, kidney disorders, liver disorders ADDITIONAL DATA: May cross the placenta. May be excreted in breast milk. 12. ECOLOGICAL INFORMATION Not available 13. DISPOSAL CONSIDERATIONS Dispose in accordance with all applicable regulations. 14. TRANSPORT INFORMATION U.S. DEPARTMENT OF TRANSPORTATION: Not regulated. CANADIAN TRANSPORTATION OF DANGEROUS GOODS: Not regulated. LAND TRANSPORT ADR: Not regulated. LAND TRANSPORT RID: Not regulated. AIR TRANSPORT IATA: Not regulated. AIR TRANSPORT ICAO: Not regulated. MARITIME TRANSPORT IMDG: Not regulated. 15. REGULATORY INFORMATION U.S. REGULATIONS: CERCLA SECTIONS 102a/103 HAZARDOUS SUBSTANCES (40 CFR 302.4): Not regulated. SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart B): Not regulated. SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart C): Not regulated. SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370 Subparts B and C): ACUTE: Yes CHRONIC: Yes FIRE: Yes REACTIVE: No SUDDEN RELEASE: No SARA TITLE III SECTION 313 (40 CFR 372.65): Not regulated. STATE REGULATIONS: California Proposition 65: Not regulated. CANADIAN REGULATIONS: WHMIS CLASSIFICATION: B2, D2B. EUROPEAN REGULATIONS: EC CLASSIFICATION (CALCULATED): F Highly flammable DANGER/HAZARD SYMBOL: EC RISK AND SAFETY PHRASES: R 11 Highly flammable. S 9 Keep container in a well-ventilated place. S 16 Keep away from sources of ignition - No smoking. S 51 Use only in well-ventilated areas. S 60 This material and its container must be disposed of as hazardous waste. 16. OTHER INFORMATION EC RISK PHRASES: R 11 Highly flammable. “RTECS®” is a United States trademark owned and licenced under authority of the U.S. Government, by and through Symyx Software, Inc. Portions ©Copyright 2001, U.S. Government. All rights reserved. Limitations: The information and recommendations set forth in this SDS are believed to be correct as of this date. Ventana Medical Systems, Inc. makes no warranty with respect to the content of this SDS and disclaims all liability from reliance thereon.