======================================================= MSDS Safety Information ======================================================= NAME: ACRYLAMIDE/BIS [29%] ======================================================= Material Safety Data Sheet Acrylamide/Bisacrylamide ACC# 61027 Section 1 - Chemical Product and Company Identification MSDS Name: Acrylamide/Bisacrylamide Catalog Numbers: BP1406-1, BP1408-1, BP1410-1 Synonyms: None known. Company Identification: Fisher Scientific 1 Reagent Lane Fair Lawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 Section 2 - Composition, Information on Ingredients CAS# Chemical Name Percent EINECS/ELINCS 7732-18-5 Water 60 231-791-2 79-06-1 Acrylamide <40 201-173-7 110-26-9 Methylenediacrylamide <3 203-750-9 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: colorless liquid. Warning! Acrylamide may cause nervous system damage. Acrylamide caused cancer and male reproductive disorders in laboratory animal tests. Harmful if swallowed, inhaled, or absorbed through the skin. Causes eye irritation. May cause allergic skin reaction. Cancer suspect agent. Light sensitive. Air sensitive. Keep refrigerated. (Store below 4°C/39°F.) Hazardous polymerization may occur. Target Organs: Eyes, nervous system, reproductive system, skin. Potential Health Effects Eye: Causes eye irritation. Acrylamide can be absorbed through the eyes and overexposure will produce the signs and symptoms of neurotoxicity described below. Skin: May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Acrylamide is readily absorbed through unbroken skin and can cause nervous system effects (neurotoxicity). These effects can result from a single overexposure but are more likely after repeated exposures to small amounts over a period of days or weeks. Signs and symptoms of overexposure include increased sweating of the hands and feet, numbness, tingling and weakness in the extremities, unsteady gait and decreased reflexes. If the exposure route is dermal, the symptoms may be preceded by peeling and redness of the skin at the areas of exposure, normally the hands and feet. Ingestion: Harmful if swallowed. May cause central, peripheral, and autonomic nervous system effects. Central nervous system effects, which appear to predominate in acute cases, are characterized by abnormal fatigue, memory difficulties, and dizziness. Peripheral neuropathy symptoms, which are more common with repeated low-dose exposure or following a latency period of up to several weeks after acute exposure can include: muscular weakness, paresthesia, numbness in hands, feet, lower legs, and lower arms, unsteadiness, and difficulties in walking and standing. Autonomic nervous system involvement is indicated by excessive sweating, peripheral vasodilation and difficulties in micturation and defecation. Inhalation: Acrylamide tends to sublime (go directly from solid to vapor form) which may lead to inhalation exposure. Acrylamide can be absorbed through the lungs and overexposure will produce the signs and symptoms of neurotoxicity described above. Chronic: Prolonged or repeated skin contact may cause dermatitis. May cause cancer according to animal studies. Adverse reproductive effects have been reported in animals. Prolonged or repeated exposure affects the nervous system. Section 4 - First Aid Measures Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid. Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Either acute or chronic exposure may lead to weak or absent reflexes, positive Romberg's sign, loss of vibration and position senses and numbness and tingling of the limbs. An early sign of toxic effects is peeling of the skin of the fingertips. Antidote: Pyridoxine (vitamin B6), pyruvate, and N-acetylcysteine have been used to reduce the toxicity of acrylamide in experimental studies, but are unproven. Section 5 - Fire Fighting Measures General Information: Pyridoxine (vitamin B6), pyruvate, and N-acetylcysteine have been used to reduce the toxicity of acrylamide in experimental studies, but are unproven. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Dust can be an explosion hazard when exposed to heat or flame. Combustible solid. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Flash Point: Not applicable. Autoignition Temperature: Not applicable. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 2; Flammability: 2; Instability: 2 Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Isolate area and deny entry. Provide ventilation. Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. Storage: Keep away from heat, sparks, and flame. Do not store in direct sunlight. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4°C/39°F.) Keep away from acids. Do not store near alkaline substances. Keep away from polymerization catalysts. Should not be exposed to temperatures above 122°F (50°C). Section 8 - Exposure Controls, Personal Protection Engineering Controls: Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Utilize a closed system process where feasible. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs Water none listed none listed none listed Acrylamide 0.03 mg/m3 TWA (inhalable fraction and vapor); Skin - potential significant contribution to overall exposure by the cutaneous r oute 0.03 mg/m3 TWA 60 mg/m3 IDLH 0.3 mg/m3 TWA Methylenediacrylamide none listed none listed none listed OSHA Vacated PELs: Water: No OSHA Vacated PELs are listed for this chemical. Acrylamide: 0.03 mg/m3 TWA Methylenediacrylamide: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear chemical splash goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - Physical and Chemical Properties Physical State: Liquid Appearance: colorless Odor: none reported pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate:Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point:Not available. Decomposition Temperature:Not available. Solubility: Soluble in water Specific Gravity/Density:Not available. Molecular Formula:Mixture Molecular Weight:Not available Section 10 - Stability and Reactivity Chemical Stability: May polymerize on exposure to light. Conditions to Avoid: Light, ignition sources, moisture, exposure to air, heat. Incompatibilities with Other Materials: Metals, oxidizing agents, reducing agents, acids, bases, peroxides. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, carbon dioxide, ammonia and/or derivatives, hydrogen gas. Hazardous Polymerization: May occur. Section 11 - Toxicological Information RTECS#: CAS# 7732-18-5: ZC0110000 CAS# 79-06-1: AS3325000 CAS# 110-26-9: AS3678000 LD50/LC50: CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg; . CAS# 79-06-1: Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 50 mg/3D Mild; Draize test, rabbit, skin: 500 mg/24H Mild; Oral, mouse: LD50 = 107 mg/kg; Oral, rabbit: LD50 = 150 mg/kg; Oral, rat: LD50 = 124 mg/kg; Skin, rabbit: LD50 = 1680 uL/kg; Skin, rat: LD50 = 400 mg/kg; . CAS# 110-26-9: Oral, mouse: LD50 = 380 mg/kg; Oral, rat: LD50 = 390 mg/kg; . Carcinogenicity: CAS# 7732-18-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65. CAS# 79-06-1: * ACGIH: A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans * California: carcinogen, initial date 1/1/90 * NTP: Suspect carcinogen * IARC: Group 2A carcinogen CAS# 110-26-9: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Epidemiology: ACGIH calls acrylamide a confirmed animal carcinogen with unknown relevance to humans. An epidemiological study involving 8854 workers, 2293 exposed to acrylamide, did not show any significant increase in cancer mortality related to acrylamide exposure. Teratogenicity: See actual entry in RTECS for complete information. Reproductive Effects: Adverse reproductive effects have occurred in experimental animals. Mutagenicity: See actual entry in RTECS for complete information. Neurotoxicity: Neurotoxic effects have occurred in humans. Other Studies: Section 12 - Ecological Information Ecotoxicity: No data available. No information available. Environmental: No information available. Physical: Log P(oct): -1.24 Other: No information available. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: CAS# 79-06-1: waste number U007. Section 14 - Transport Information US DOT Canada TDG Shipping Name: ACRYLAMIDE SOLUTION ACRYLAMIDE SOLUTION Hazard Class: 6.1 6.1 UN Number: UN3426 UN3426 Packing Group: III III Section 15 - Regulatory Information US FEDERAL TSCA CAS# 7732-18-5 is listed on the TSCA inventory. CAS# 79-06-1 is listed on the TSCA inventory. CAS# 110-26-9 is listed on the TSCA inventory. Health & Safety Reporting List CAS# 79-06-1: Effective 10/4/82, Sunset 10/4/92 Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs CAS# 79-06-1: 5000 lb final RQ; 2270 kg final RQ SARA Section 302 Extremely Hazardous Substances CAS# 79-06-1: 1000 lb lower threshold TPQ; 10000 lb upper threshold TP Q SARA Codes CAS # 79-06-1: immediate, delayed, sudden release of pressure, reactive. CAS # 110-26-9: immediate, delayed, reactive. Section 313 This material contains Acrylamide (CAS# 79-06-1, <40%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. Clean Air Act: CAS# 79-06-1 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ. CAS# 79-06-1 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts. CAS# 110-26-9 is not present on state lists from CA, PA, MN, MA, FL, or NJ. California Prop 65 WARNING: This product contains Acrylamide, a chemical known to the state of California to cause cancer. California No Significant Risk Level: CAS# 79-06-1: 0.2 æg/day NSRL European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T Risk Phrases: R 20/21 Harmful by inhalation and in contact with skin. R 25 Toxic if swallowed. R 36/38 Irritating to eyes and skin. R 43 May cause sensitization by skin contact. R 45 May cause cancer. R 46 May cause heritable genetic damage. R 48/23/24/25 Toxic : danger of serious damage to health by prolonged exposure through inhalation, contact with skin and if swallowed. R 62 Possible risk of impaired fertility. Safety Phrases: S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S 53 Avoid exposure - obtain special instructions before use. WGK (Water Danger/Protection) CAS# 7732-18-5: No information available. CAS# 79-06-1: 3 CAS# 110-26-9: 2 Canada - DSL/NDSL CAS# 7732-18-5 is listed on Canada's DSL List. CAS# 79-06-1 is listed on Canada's DSL List. CAS# 110-26-9 is listed on Canada's DSL List. Canada - WHMIS This product has a WHMIS classification of D1B, D2A. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations. Canadian Ingredient Disclosure List CAS# 79-06-1 is listed on the Canadian Ingredient Disclosure List. Section 16 - Additional Information MSDS Creation Date: 7/12/1999 Revision #8 Date: 8/07/2008 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.