Conforms to 93/112/EC and ISO 11014-1 Material Safety Data Sheet ImmunoPureŽ IgG Elution Buffer, 50 Ml 3831 1856202 CALL CHEMTREC: 800.424.9300 OUTSIDE US: 202.483.7616 3/13/2003 3/13/2003 Product name Supplier Manufacturer Product No. MSDS# Validation Date Print Date In Case of Emergency Section 1. Chemical Product and Company Identification Responsible Name Pierce Administration Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. Eng In USA: In Europe: Pierce Perbio Science P.O. Box 117 Industriezone III Rockford, IL 61105 Industrielaan 27 USA 9320 Erembodegem-Aalst 815.968.0747 or Belgium 1.800.874.3723 Tel:+32 53 83 44 04 Fax:+32 53 83 76 38 Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 USA 815.968.0747 or 1.800.874.3723 1) Elution Buffer Ingredient 2 0.1-1 200-272-2 Xi R36 Ingredient Name EC Number CAS No. R-Phrases Substance/Preparation Preparation % Symbol : Section 2. Composition, Information on Ingredients Physical/chemical hazards Human health hazards Environmental hazards Not applicable. Not applicable. Not applicable. Absorbed through skin. Eye contact. Inhalation. Ingestion. Emergency Overview Medical Conditions Aggravated by Overexposure: Repeated or prolonged exposure is not known to aggravate medical condition. Not available. Overexposure /Signs/Symptoms Section 3. Hazards Identification Routes of Entry Potential Acute Health Effects Carcinogenic Effects Data See Toxicological Information (section 11) Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation (lung irritant). CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. Review the most current and approved institutional guideline, protocol, standard operating procedure(s) and MSDS(s) for the proper handling of institutional materials/equipment associated with the use of this product. No specific hazard. Classification R36/37/38 United States Europe Continued on Next Page ImmunoPureŽ IgG Elution Buffer, 50 Ml Page: 2/6 Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Skin Contact Ingestion Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Slightly hazardous in case of inhalation (lung irritant). Not available. Sensitization of the product: Not available. Slightly hazardous in case of skin contact (irritant). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Skin Contact Slightly hazardous in case of eye contact (irritant). Eye Contact Inhalation Aggravating conditions Repeated or prolonged exposure is not known to aggravate medical condition. First-Aid Measures If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention if symptoms appear. Notes to Physician Not available. Not available. Protection of first-aiders Ingestion Effects and symptoms Inhalation Eye Contact Section 4. First Aid Measures Notice to Reader Get immediate medical attention. Hazardous thermal (de)composition products Not applicable. Non-flammable. Not applicable. Not applicable. Not applicable. Section 5. Fire Fighting Measures Flammability of the Product Flash Points Fire Hazards in Presence of Various Substances Fire Fighting Media and Instructions Not applicable. Protective Clothing (Fire) Absorb with an inert material and put the spilled material in an appropriate waste disposal. Neutralize the residue with a dilute solution of sodium carbonate. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 6. Accidental Release Measures Small Spill and Leak Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. If necessary: Neutralize the residue with a dilute solution of sodium carbonate. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Environmental Precautions and Clean-up Methods Personal precautions Safety glasses. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Keep container tightly closed. Keep container in a cool, well-ventilated area. Store between 2 to 8°C (35.6 to 46.4°F). Avoid breathing vapors or spray mists. Section 7. Handling and Storage Handling Storage Packaging materials Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. Continued on Next Page ImmunoPureŽ IgG Elution Buffer, 50 Ml Page: 3/6 Suitable / Not suitable Use original container. 1) Elution Buffer Ingredient 2 Not available. Germany 1) Elution Buffer Ingredient 2 Not available. Netherlands 1) Elution Buffer Ingredient 2 Not available. France 1) Elution Buffer Ingredient 2 Not available. Norway 1) Elution Buffer Ingredient 2 Not available. Denmark 1) Elution Buffer Ingredient 2 Not available. Sweden United States Ingredient Name Occupational Exposure Limits Engineering Controls Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Section 8. Exposure Controls/Personal Protection Exposure Limit Values Personal Protection Eyes Body Protective Clothing (Pictograms) Safety glasses. Lab coat. The lowest known value is 100°C (212°F) (Milli-Q Water). Liquid. 2.8 [Acidic.] May start to solidify at -0.1°C (31.8°F) based on data for: Milli-Q Water. The only known value is 1 (Water = 1) (Milli-Q Water). The highest known value is 0.62 (Air = 1) (Milli-Q Water). The highest known value is 2.3 kPa (@ 20°C) (Milli-Q Water). See solubility in water. Not applicable. Not available. Not available. Not available. Boiling/Condensation Point Melting/Freezing Point 0.36 (Milli-Q Water) compared to Butyl acetate. Physical State and Appearance Molecular Weight pH (1% Soln/Water) Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Dispersion Properties Odor Taste Color Section 9. Physical and Chemical Properties Continued on Next Page ImmunoPureŽ IgG Elution Buffer, 50 Ml Page: 4/6 Soluble in cold water, hot water. Insoluble in diethyl ether. Solubility The product is stable. Not available. Will not occur. Not available. Section 10. Stability and Reactivity Stability and Reactivity Conditions to avoid Materials to avoid Hazardous Polymerization Hazardous Decomposition Products Not applicable. LD50: Not available. LC50: Not available. Slightly hazardous in case of eye contact (irritant), of inhalation (lung irritant). Not available. Not available. Not available. Not available. Section 11. Toxicological Information Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Special Remarks on Toxicity to Animals Special Remarks on Chronic Effects on Humans Special Remarks on Other Toxic Effects on Humans Ecotoxicity Not available. Mobility Germany water class Not available. Not available. Not available. Persistence/degradability Bioaccumulative potential VCI WGK: No products were found. Section 12. Ecological Information Waste must be disposed of in accordance with federal, state and local environmental control regulations. Not available. Waste Information Waste Stream Section 13. Disposal Considerations Consult your local or regional authorities. Contact the supplier for all information regarding the proper transportation method for this material. Section 14. Transport Information Continued on Next Page ImmunoPureŽ IgG Elution Buffer, 50 Ml Page: 5/6 U.S. Federal Regulations No products were found. -- HCS Classification Section 15. Regulatory Information California prop. 65: No products were found. TSCA 8(b) inventory: Milli-Q Water; Elution Buffer Ingredient 2 Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: No products were found. Clean air act (CAA) 112 accidental release prevention: No products were found. Clean air act (CAA) 112 regulated flammable substances: No products were found. Clean air act (CAA) 112 regulated toxic substances: No products were found. State Regulations CEPA DSL: Milli-Q Water; Elution Buffer Ingredient 2 Australia (NICNAS): Milli-Q Water; Elution Buffer Ingredient 2 Korea (TCCL): Milli-Q Water; Elution Buffer Ingredient 2 Philippines (RA6969): Milli-Q Water; Elution Buffer Ingredient 2 WHMIS (Canada) Not controlled under WHMIS (Canada). This product is not classified according to the EU regulations. DSCL (EEC) International Regulations Not available. EINECS International Lists SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: No products were found. SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found. SARA 313 toxic chemical notification and release reporting: No products were found. This product is not classified according to the EU regulations. Label Requirements (Europe) 1 Version 0.02 Date of Previous Issue No Previous Validation Not available. Section 16. Other Information References Validated by Pierce Administration on 3/13/2003. Verified by Pierce Administration. Printed 3/13/2003. Hazardous Material Information System (U.S.A.) 1 0 0 g 0 0 1 National Fire Protection Association (U.S.A.) Health Specific Hazard Reactivity Fire Hazard Health Fire Hazard Reactivity Personal Protection History of Document Changes Any information changes since last document version are marked with a triangle symbol. Irritating to eyes. Full text of R-Phrases referenced under headings 2 and 3: Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. Continued on Next Page ImmunoPureŽ IgG Elution Buffer, 50 Ml Page: 6/6 Notice to Reader To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.