QIAGEN INC -- BUFFER N3, BUFFER N3 (500 ML), 19064 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 11/06/1998 MSDS Num: CJVCH LIIN: 00N092805 Product ID: BUFFER N3, BUFFER N3 (500 ML), 19064 MFN: 01 Responsible Party Cage: 01QT0 Name: QIAGEN INC Address: 28159 AVE STANFORD City: SANTA CLARITA CA 91355 Info Phone Number: 800-362-7737 Emergency Phone Number: 800-362-7737 Published: Y ======================================================= Contractor Summary ======================================================= Cage: 01QT0 Name: QIAGEN INC Address: 28159 AVENUE STANFORD City: SANTA CLARITA CA 91355 Phone: 800-362-7737 ======================================================= Item Description Information ======================================================= ======================================================= Ingredients ======================================================= Cas: 127-08-2 RTECS #: AJ3325000 Name: POTASSIUM ACETATE. LD50: (ORAL,RAT) 3250 MG/KG ------------------------------ Cas: 64-19-7 RTECS #: AF1225000 Name: ACETIC ACID. LD50: (ORAL,RAT) 3310 MG/M3 OSHA PEL: 25 MG/M3;10 PPM ACGIH TLV: 25 MG/M3;10 PPM ACGIH STEL: 37 MG/M3;15 PPM EPA Rpt Qty: 5000 LBS DOT Rpt Qty: 5000 LBS ------------------------------ Cas: 50-01-1 RTECS #: MF4300000 Name: GUANIDINE HYDROCHLORIDE. LD50: (ORAL,RAT) 475 MG/KG ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE INGREDIENTS Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: NEUTRALIZATION BUFFER N3: AQUEOUS SOLUTION OF POTASSIUM ACETATE, ACETIC ACID, AND GUANIDINE HYDROCHLORIDE. POTASSIUM ACETATE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CA USE IRRITATION. WARNING: HYGROSCOPIC. ACETIC ACID: HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. MATERIAL IS DESTRUCTIVE TO TISSUE OF MUCOUS MEMBRANES & UPPER RESPIRATORY TRACT. INHALATON MAY BE FATAL AS RESULT OF SPASM, INFLAMMATION & EDEMA OF LARYNX & BRONCHI, CHEMICAL PNEUMONITIS & PULMONARY EDEMA. MATERIAL IS DESTRUCTIVE TO EYES & SKIN. WARNING: CORROSIVE, COMBUSTIBLE (EFTS OF OVER EXP) Signs And Symptions Of Overexposure: HLTH HAZS: (USA DEFINITION), FLAMMABLE (EUROPEAN DEFINITION). GUANIDINE HYDROCHLORIDE: HARMFUL IF SWALLOWED, INHALED/ABSORBED THROUGH SKIN. CAUSES SEVERE IRRIT. HIGH CONCS ARE EXTREMELY DESTRUCTIVE TO TISSUES OF MUC MEMB & UPPER RESP TRACT,EYES & SKIN. SYMPS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING, WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUS & VOMITING. MAY CAUSE NERVOUS SYSTEM DISTURBANCES. TARGET ORGAN(S): BONE MARROW, NERVES. WARNING: TOXIC (USA DEFINITION) HARMFUL (EUROPEAN DEFINITION). First Aid: EYE CONT: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING OF EYES BY SEPARATING EYELIDS WITH FINGERS. SKIN CONT: IMMEDIATELY WASH WITH SOAP AND COPIOU S AMOUNTS OF WATER. INHAL: REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGEST: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CA LL PHYSICIAN. REMOVE AND WASH CONTAMINATED CLOTHING PROMPTLY. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: PRECAUTIONARY MEASURES: WEAR NIOSH APPRVD SELF-CONTAINED BREATHING APPARATUS, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS, AND HEAVY RUBBER GLOVES. CLEAN-UP PROCEDURE: ABSORB ON SAND OR VERMICULITE AND PLAC E IN CLOSED CONTAINERS FOR DISPOSAL. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: THERE ARE NO UNIFORM REGS FOR DISP OF CHEMICALS OR RESIDUES. CHEMICAL RESIDUE GENERALLY COUNT AS SPECIAL WASTE. WE RECOMMEND THAT YOU CONTACT EITHER AUTHORITIES IN CHARGE OR APPRVD WASTE DISPOSAL COMP ANIES WHICH WILL ADVISE YOU ON HOW TO DISPOSE OF SPECIAL WASTE. HANDLE CONTAMINATED (SUPDAT) Handling And Storage Precautions: HARMFUL IF SWALLOWED. IRRITATING TO EYES AND SKIN. LABELING: XN, HARMFUL, R 22-36/38. ADDITIONAL INFORMATION: THE PRODUCT SHOULD BE HANDLED WITH THE NORMAL CAUTION ACCORDED CHEMICALS. ADDITIONAL HARMF UL PROPERTIES CANNOT BE RULED OUT. Other Precautions: STORE TIGHTLY CLOSED AT 20-25C. ======================================================= Fire and Explosion Hazard Information ======================================================= Flash Point: =54.C, 129.2F Extinguishing Media: NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS. Fire Fighting Procedures: USE NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS AND FULL PROTECTIVE EQUIPEMENT (FP N) TO PREVENT CONTACT WITH SKIN AND EYES. ======================================================= Control Measures ======================================================= Respiratory Protection: NIOSH APPROVED RESPIRATOR. Protective Gloves: RUBBER GLOVES. Eye Protection: ANSI APPRVD CHEM WORKERS GOGG (FP N). FACESHIELD (8-INCH MINIMUM). Other Protective Equipment: EYE WASH & DELUGE SHOWER MEETING ANSI DESIGN CRITERIA (FP N). Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. Supplemental Safety and Health: WASTE DISP METH: PACKAGING IN SAME WAY AS SUBSTANCE ITSELF. UNLESS SPECIFIED DIFFERENTLY, NONCONTAMINATED PACKAGING MAY BE TREATED LIKE HOUSEHOLD WASTE OR RECYCLED. DISPOSAL MUST BE I/A/W FEDERAL, STA TE AND LOCAL REGULATIONS (FP N). ======================================================= Physical/Chemical Properties ======================================================= Spec Gravity: 1.14 G/CM3 PH: 4.3 Solubility in Water: SOLUBLE Appearance and Odor: COLORLESS LIQUID. CHARACTERISTIC ODOR. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Materials To Avoid: STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDE, AND HYDROGEN CHLORIDE GAS. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= Toxicological Information: POTASSIUM ACETATE: ORL-RAT LD50:3250 MG/KG AIHAAP 30,470,69. ACETIC ACID: UNR-MAN LDLO: 308 MG/KG 85DCAI 2,73,70. ORL-RAT LD50:3310 MG/KG DMDJAP 31,276,59. IHL-MUS LC50: 56200 PPM/H MELAAD 48,559,57. IVN-MUS LD50:525 MG/KG APTOA6 18,141,61. SKN-RBT LD50: 1060 MG/KG UCDS 8/7/63. GUANIDINE HYDROCHLORIDE: ORL-RAT LD50: 475 MG/KG NTIS AD-A165-747. IPR-MUS LD50: 500 MG/KG NTIS AD277-689. ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ACUTE EFTS: INHAL: MAY BE HARMFUL BY INHAL. MATL IS (OTHER INFO ) ======================================================= Ecological Information ======================================================= ======================================================= MSDS Transport Information ======================================================= ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: LABELING: XN, HARMFUL, R 22-36/38. ======================================================= Other Information ======================================================= Other Information: TOX INFO: DESTRUCTIVE TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. EYE CONTACT: MATERIAL IS DESTRUCTIVE TO EYES. SKIN CONTACT: MATERIAL IS DESTRUCTIVE TO SKIN. HARMFUL BY SKIN ABSORPTION. I NGESTION: HARMFUL IF SWALLOWED. PROLONGED EXPOSURE: N/A. CHRONIC EFFECTS: N/A. ======================================================= HAZCOM Label ======================================================= Product ID: BUFFER N3, BUFFER N3 (500 ML), 19064 Cage: 01QT0 Company Name: QIAGEN INC Street: 28159 AVENUE STANFORD City: SANTA CLARITA CA Zipcode: 91355 Health Emergency Phone: 800-362-7737 Label Required IND: Y Date Of Label Review: 04/13/2000 Status Code: C Origination Code: F Eye Protection IND: YES Skin Protection IND: YES Signal Word: DANGER Respiratory Protection IND: YES Health Hazard: Severe Contact Hazard: Severe Fire Hazard: Moderate Reactivity Hazard: None Hazard And Precautions: CORROSIVE, COMBUSTIBLE! ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE IRRITATION. MATERIAL IS DESTRUCTIVE TO TISSUE OF MUCOUS MEMBRANES & UPPER RESPIRATORY TRACT. INH ALATON MAY BE FATAL AS RESULT OF SPASM,INFLAMMATION & EDEMA OF LARYNX & BRONCHI, CHEMICAL PNEUMONITIS & PULMONARY EDEMA. MATERIAL IS DESTRUCTIVE TO EYES & SKIN. CHRONIC: NONE SPECIFIED BY MANUFACTURE R (FP N). ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.