NA = not applicable NL = not listed NE = not established NNR = not normally required INNOVATIONS FOR SCIENCE TRIANGLE BIOMEDICAL SCIENCES, INC. 3014 CROASDAILE DRIVE • DURHAM, NORTH CAROLINA 27705-2507 • USA • 919.384.9393 • FAX 919.384.9595 • E-MAIL: tbs@trianglebiomedical.com Date Issued: November 19, 2008 Supersedes Date: October 6, 2005 MATERIAL SAFETY DATA SHEET IDENTIFICATION AND EMERGENCY INFORMATION Product Name TMD™ Tissue Marking Dye Red Product Code (Catalog Number) TMD-R (Red) Product Category (Chemical Name) Dyes Product Appearance and Odor Liquid of red Emergency Notification Chem-Tel 1-800-255-3924 International 813-248-0585 COMPONENTS AND HAZARD INFORMATION Component CAS No. % OSHA TWA ppm mg/m3 OSHA STEL ppm mg/m3 N,N-dimethylethanolamine 000108010 <2 NE NE NE NE 2-Aminoethanol 000141435 <2 NA 6 NL NL Formaldehyde 000050000 <1 NL 2/15 NL NL Water 007732185 <66 NE NE NE NE PHYSICAL DATA THE FOLLOWING DATA ARE APPROXIMATE OR TYPICAL VALUES AND SHOULD NOT BE USED FOR PRECISE DESIGN PURPOSES. Boiling Range Specific Gravity Molecular Weight Viscosity >212 1.02 NL NL Percent Volatile by Volume Vapor Pressure @20 C degrees Vapor Density (Air = 1) Pour, Congealing or Melting Point NE NE NE 32 F Solubility in Water @1 ATM and 25oC (77oF) Evaporation Rate @1 ATM and 25oC (77oF) (n-Butyl Acetate =1) pH NE NE NE FIRE AND EXPLOSION HAZARD INFORMATION Flash Point (Minimum) Autoignition Temperature Test Mode LEL UEL NE NE NE NE National Fire Protection Association (NFPA) — Hazard Identification Health Flammability Reactivity Basis NL NE NE TBS Material Safety Data Sheet TMD-R Page 2 of 2 NA = not applicable NL = not listed NE = not established NNR = not normally required INNOVATIONS FOR SCIENCE Handling Precautions Use standard safety precautions. Flammable or Explosive Limits (Approximate Percent by Volume in Air) NE Extinguishing Media Water, carbon dioxide, dry chemical powder, foam. Fire Fighting Procedures Firefighters must wear self-contained breathing apparatus and fully protective equipment. Fire water run-off should be diverted from adjacent waterways. Decomposition Products Under Fire Condition NE “Empty” Container Warning Use same applicable regulations as formaldehyde. Unusual Fire and Explosion Hazards Use water spray to disperse vapor. HEALTH AND HAZARD INFORMATION Variability Among Individuals NE Signs and symptoms of overexposure Chemical, physical and toxicological properties are not established for this material. Handle with the care required by good laboratory technique. Effects of Overexposure Continual contact of the skin may cause discoloration of skin in contact area. Nature of Hazard and Toxicity Information NL Pre-existing Medical Conditions which may be Aggravated by Exposure Conditions of the skin. Threshold Limit Value NL Health Hazards Possible skin irritant. Carcinogenicity NL PRIMARY ROUTES OF ENTRY AND EMERGENCY AND FIRST AID PROCEDURES Eye Contact Flush eyes with water for at least 15 minutes while holding lids open. Do not remove contact lenses if worn. Contact physician immediately. TBS Material Safety Data Sheet TMD-R Page 3 of 3 NA = not applicable NL = not listed NE = not established NNR = not normally required INNOVATIONS FOR SCIENCE Skin Wash affected area with copious amounts of water for at least 15 minutes. Wash contaminated clothing. Inhalation Remove to fresh air. Give oxygen or artificial respiration, as needed. Contact emergency personnel Ingestion Induce vomiting as directed by medical personnel. SEEK MEDICAL TREATMENT IF DISCOMFORT PERSISTS. REACTIVITY Stability Incompatibility Hazardous Decomposition Products Stable NE NE Conditions to Avoid Hazardous Polymerization Materials to Avoid High temperature Will not occur ENVIRONMENTAL INFORMATION Steps to be Taken in Case Material is Released or Spilled Contain spilled liquid with non-combustible materials. This product contains formaldhyde (50- 00-0) 0.05% of which is RCRA U122. Fire water run-off should be diverted from adjacent waterways. Waste Disposal Method Regualtions – RCRA U122 listed waste. Discard supplied material according to Federal Regulations (40 CFR 261). It is to be determined by the user weather material at the time of disposal is subject to RCRA restrictions. Disposal Responsibility for proper disposal of waste lies with the party generating the waste. Transportation, storage and disposal of waste material must comply with 40 CFR 262, 263, 264, 268 and 270. Check with all federal, state and local regulations for applicable requirements. Protective Gear Ware gloves, goggles and appropriate clothing during handling. Practice good hygine. Precautions to be taken in handling and storage Store material at 25oC. Keep storage container tightly closed. Avoid contact with skin and eyes. Do not inhale dried material. Wash thoroughly after handling. Do not cut, grind, weld, or reuse container unless adequate measures are taken. Do not eat, drink or smoke in storage areas. THE FOLLOWING INFORMATION MAY BE USEFUL IN COMPLYING WITH VARIOUS STATE AND FEDERAL LAWS AND REGULATIONS UNDER VARIOUS ENVIRONMENTAL STATUTES. Reportable Quantity (RQ), EPA Regulation 40 CFR 302 (CERCLA Section 102) NE TBS Material Safety Data Sheet TMD-R Page 4 of 4 NA = not applicable NL = not listed NE = not established NNR = not normally required INNOVATIONS FOR SCIENCE Threshold Planning Quantity (TPQ), EPA Regulation 40 CFR 355 (SARA Sections 301-304) NNR Toxic Chemical Release Reporting, EPA Regulation 40 CFR 372 (SARA Section 313) Ammonia 7664-41-7 <2% Hazardous Chemical Reporting, EPA Regulation 40 CFR 370 (SARA Sections 311-312) Acute Hazard Chronic Hazard Fire Hazard Pressure Hazard Reactive Hazard Not Applicable NE NE NL NL NE SPECIAL STATE NOTIFICATIONS California: This product contains a substance known to the state of California to cause cancer. PROTECTION AND PRECAUTIONS Ventilation Mechanical ventilation sufficient to keep below TLVs Respiratory Protection OSHA/MHSA approved respirator if needed. Protective Gloves Rubber Eye Protection Safety goggles. Other Protective Equipment Safety shower, eye bath. TRANSPORTATION AND OSHA RELATED LABEL INFORMATION Transportation Incident Information NL U.S. DOT Hazardous Materials Shipping Description Non-Regulate, dye OSHA Required Label Information NL TRIANGLE BIOMEDICAL SCIENCES (TBS) provides the information contained herein in good faith, but makes no representation as to its comprehensiveness or accuracy. Individuals receiving this information must exercise their independent judgement in determining its appropriateness for a particular purpose. TBS makes no representation or warranties, either expressed or implied of merchantability, fitness for particular purposes with respect to the information set forth herein or to which the information refers. Accordingly, TBS will not be responsible for damages resulting from the use of or reliance upon this information.