Material Safety Data Sheet MSDS Preparation Date: 21/05/2008
MSDS Revision Date: 22/05/2011
(-)-Bicuculline methochloride Cat. No: 0131 Batch No: 31
[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-
dioxolo[4,5-g]isoquinolinium chloride
1. COMPOSITION/INFORMATION ON INGREDIENTS
For batch specific information, please see Product Information sheet.
2. PHYSICAL AND CHEMICAL PROPERTIES
For batch specific information, please see Product Information sheet.
3. HANDLING AND STORAGE
Use in a chemical fume hood, with air supplied by an independent system.
Avoid inhalation, contact with eyes, skin and clothing. Avoid prolonged or
repeated exposure.
Material should be stored in a tightly sealed container under the storage
condition stated on the Product Information sheet and on the vial label.
4. STABILITY AND REACTIVITY
Stability: Stable under normal handling conditions.
Conditions to avoid: Not applicable for this product
Hazardous Combustion/Decomposition of Product: May emit toxic gases
such as carbon dioxide, carbon monoxide and nitrogen oxide upon thermal
decomposition.
5. HAZARDS IDENTIFICATION
RTECS substance category: Agricultural chemical; Natural product.
Exposure may cause irritation to eyes, mucous membranes, upper
respiratory tract and skin
6. TOXICOLOGICAL INFORMATION
To the best of our knowledge, the chemical, physical and toxicological
properties have not been fully investigated.
Only selected Registry of Toxic Effects of Chemical Substances (RTECS)
data is presented above. See actual entry in RTECS for complete
information.
7. REGULATORY INFORMATION
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or
absorbed through skin
RTECS No: LV0909840 [(+)-Bicuculline]
Target Organs: Eyes; Respiratory sytem; Skin
Toxicity Data: Data relates to (+)-Bicuculline: IPR-MUS LD50: 8480µg/kg
Safety Phrases: S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and
eye/face protection
S45 - In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible)
Risk Phrases: R23/24/25 - Toxic by inhilation, in contact with skin and if
swallowed
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Wear appropriate chemical resistant gloves, safety goggles and other
protective clothing to prevent contact with eyes and skin. Laboratory should
be equipped with a safety shower and eye wash station. Avoid prolonged or
repeated exposure. Do not breathe dust. Do not get in eyes, on skin or on
clothing. Wash thoroughly after handling.
9. FIRST-AID MEASURES
In cases of SKIN CONTACT: Wash with copious amounts of water for at
least 15 minutes. Remove contaminated clothing and shoes and wash before
wearing. In case of eye contact, flush with copious amounts of water for at
least 15 minutes.
In cases of INHALATION: Remove to fresh air and monitor breathing. If
breathing becomes difficult, give oxygen. If breathing stops, give artificial
respiration.
In cases of INGESTION: If swallowed, rinse mouth out with water, contact
local poison centre and call a physician.
10. FIRE-FIGHTING MEASURES
Extinguishing Media: Material is non-combustible. Use extinguishing media
appropriate to surrounding fire conditions.
Unusual Fire and Explosive Hazards: May emit toxic gases upon thermal
decomposition.
Special Fire-Fighting Procedures: Wear protective clothing to prevent contact
with skin and eyes.
11. ACCIDENTAL RELEASE MEASURES
Wear appropriate protective clothing. Cover spillage with suitable absorbent
material. Using non-spark tools, sweep up material and place in an
appropriate container. Decontaminate spill site with with 10% caustic solution
and ventilate area until after disposal is complete. Hold all material for
appropriate disposal as described under DISPOSAL CONDITIONS.
12. ECOLOGICAL INFORMATION
Data not yet available - treat as potentially toxic if released into the
environment.
13. DISPOSAL CONDITIONS
As specific country, federal, state and local environmental regulations are
varied and change frequently, we recommend that you contact your local
department for Health Services for information on the correct disposal of this
product.
14. TRANSPORT INFORMATION
U.N.Number: UN1544
Proper Shipping Name: Alkaloid salts, solid, n.o.s.
IATA Class: 6.1
IATA Packing Group: III
15. OTHER INFORMATION
Due to the nature of this material. It must only be handled by suitably
qualified experienced scientists in appropriately equipped and authorised
facilities. The above information is believed to be correct but does not purport
to be all inclusive and should be used as a guide only for experienced
personnel. Always consult your safety advisor and follow appropriate local
and national safety legislature. The absence of warning must not, under any
circumstance, be taken to mean that no hazard exists.
Product Information
(-)-Bicuculline methochloride Cat. No: 0131 Batch No: 31
[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-
dioxolo[4,5-g]isoquinolinium chloride
Description:
Methochloride salt of (+)-bicuculline. Water soluble and more
stable than bicuculline. Non-GABA receptor-mediated actions
reported.
Physical and Chemical Properties:
Batch Molecular Formula: C21H20ClNO6.H2O
Batch Molecular Weight: 435.87
CAS Number: [53552-05-9]
Physical Appearance: Pale yellow solid
Batch Molecular Structure:
Storage: Store at RT
Solubility: Water to 100 mM
Phosphate buffered saline to 100 mM
Stability and Solubility Advice:
Some solutions can be difficult to obtain and can be
encouraged by rapid stirring, sonication or gentle warming
(in a 45-60°C water bath).
Information concerning product stability, particularly in
solution, has rarely been reported and in most cases we
can only offer a general guide. Our standard
recommendations are:
SOLIDS: Provided storage is as stated on the product label
and the vial is kept tightly sealed, the product can be stored
for up to 6 months from date of receipt.
SOLUTIONS: We recommend that stock solutions, once
prepared, are stored aliquoted in tightly sealed vials at -20°
C or below and used within 1 month. Wherever possible
solutions should be made up and used on the same day.
Other Information:
References:
Kemp et al (1986) Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat
hippocampal slice preparation. Br.J.Pharmacol. 87 677. Seutin and Johnson (1999) Recent advances in the pharmacology
of quaternary salts of bicuculline. TiPS 20 268.