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MATERIAL SAFETY DATA SHEET
Section 1 Company and Product Identication
Product Name
CORTISOL CALIBRATORS
S0, S1, S2, S3, S4, S5
..
Doc. ID: 33605-75 AB
.
Revised (year/month/day) 2008/01/04
Part Number
33605
Product Use
For In Vitro Diagnostic Use. See product literature for details.
Series Name
ACCESS
(r)
Manufacturer
Beckman Coulter, Inc.
4300 Harbor Blvd.
Fullerton, CA 92835-3100, U.S.A.
EC REP Address
Beckman Coulter Ireland Inc.
Mervue Business Park
Mervue, Galway, Ireland 353 91 774068
Distributor and
Emergency Phone No.
Refer to attached list, Document ID:
472050
, for local distributor
and emergency phone numbers.
Section 2 Hazards Identication
Emergency Overview
Amber; Clear; Liquid; Musty
Nonammable solution.
Skin, eye and respiratory tract irritant.
Potential sensitizer.
Contains material of human origin.
Physical Hazards
Sodium azide forms explosive compounds with heavy metals. This product
contains concentrations of azide <0.1% (w/w) which with repeated contact
with lead and copper commonly found in plumbing drains may result in
the build up of shock sensitive compounds.
Potential Health
Effects Summary
Exposure may result in irritation of skin, eyes, and mucous membranes.
This product contains material of human origin and should be considered as
potentially capable of transmitting infectious diseases.
See Section 11 Toxicological Information for more detailed health information.
Potential
Environmental Effects
No information available.
Product Hazard
Classications
Meets Hazardous Criteria for Preparation/Mixture
EU:
Xi;R43
.
WHMIS:
Exempt
US OSHA:
Not applicable
(c)2008 Beckman Coulter, Inc.
Global MSDS  English
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Section 3 Composition and Information on Ingredients
Hazardous Ingredients:
Hazard Classication of Pure Ingredients
Chemical Name
CAS #
EINECS #
% by wt.
EU
WHMIS
US OSHA
ProClin* 300
Not available Not available
<0.5
C;R34
N ;R50-53
T;R23/24/25-43
D2B
Corrosive
Sensitizer
Toxic
See Section 15 Regulatory Information for additional information on hazard classications.
See Section 16 for Risk Phrases and WHMIS Classication Description.
Section 4 First Aid Measures
Inhalation
If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin articial respiration immediately and obtain medical attention.
Eye Contact
If product enters eyes, wash eyes gently under running water for 15
minutes or longer, making sure that the eyelids are held open. If pain
or irritation occur, obtain medical attention.
Skin Contact
In case of skin contact, ush with copious amounts of water for at
least 15 minutes. Remove contaminated clothing and shoes. If pain
or irritation occur, obtain medical attention.
Ingestion
If ingested, wash mouth out with water.
If irritation or discomfort
occurs, seek medical attention.
Section 5 Fire Fighting Measures
Flammable Properties
Nonammable solution.
Extinguishing Media
Use extinguishing media suitable for surrounding re.
Special Fire and Explosion
Hazards
No special hazards determined.
Hazardous Combustion
Products
Due to the composition and volume of this product, combustion products
generated from it are not expected to present a signicant hazard.
Protective Equipment
for Fireghters
Self-contained breathing apparatus is recommended for reghters.
Section 6 Accidental Release Measures
Personal Precautions
This product contains a material of biological origin. Use universal
precautions during clean up procedures.
Spill and Leak
Procedures
As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Absorb liquid and place in container suitable for disposal. Avoid generation of
aerosols during clean up. Comply with applicable waste disposal regulations.
Environmental
Precautions
Contain spill to prevent migration.
CORTISOL CALIBRATORS
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Doc. ID: 33605-75 AB
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Section 7 Handling and Storage
Handling Precautions
This product should be handled as though capable of transmitting infectious
diseases. Universal precautions should be followed when using this product.
Recommended Storage
Conditions
Keep away from incompatible material (see Section 10).
To maintain efcacy, store according to the instructions in the product labeling.
Section 8 Exposure Controls and Personal Protection
Exposure Limits
US OSHA:
None established
ACGIH:
None established
DFG MAK:
None established
NIOSH
None established
Japan
None established
Engineering Controls
No special engineering controls are required. Use with good general ventilation.
Respiratory Protection
Under normal conditions, the use of this product should not require respiratory
protection. If aerosols are generated during use, the use of respiratory
protection should be evaluated by a qualied professional.
Eye Protection
Safety glasses or chemical goggles should be worn to prevent eye contact.
Skin Protection
Impervious gloves, such as Nitrile or equivalent, should be worn
to prevent skin contact.
Section 9 Physical and Chemical Properties
Physical State
Liquid
Color
Amber
Transparency
Clear
Odor
Musty
Odor Threshold
Not applicable
pH
7.2
Freezing Point
Not available
Boiling Point
Not available
Flash Point
Not applicable
Evaporation Rate
Not available
Flammability (Solid, Gas)
Not applicable
Flammable Limits
Not applicable
Vapor Pressure
Not available
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Section 9 Physical and Chemical Properties
(Continued)
Vapor Density
Not available
Specic Gravity
1.021 @20°C
Solubility
Water
Miscible
Organic
Not available
Coefcient of Water/Oil
Distribution
Not available
Autoignition Temp.
Not applicable
Decomposition Temperature
Not available
Percent Volatiles
Not applicable
Section 10 Stability and Reactivity
Stability
Stable under normal temperatures and pressures.
Hazardous Incompatibilities
Metals and metallic compounds
Strong oxidizers
Strong acids
Strong bases
Sodium azide forms explosive compounds with heavy metals. This product
contains concentrations of azide <0.1% (w/w) which with repeated contact
with lead and copper commonly found in plumbing drains may result in
the build up of shock sensitive compounds.
Hazardous Decomposition
Products
No decomposition products posing signicant hazards would be
expected from this product.
Conditions to Avoid
Keep away from incompatible material.
Section 11 Toxicological Information
Toxicity Data
for Hazardous Ingredients
Not applicable
Primary Routes
of Exposure
Common routes of entry include inhalation, ingestion and eye/skin contact. Specic
paths of concern for potentially infectious materials are skin puncture, contact with
broken skin, contact with mucous membranes and inhalation of aerosolized material.
Potential Effects of
Acute Exposure
Exposure to ProClin 300 may result in irritation of skin, eyes and mucous
membranes. Skin contact may result in possible sensitization. Eye contact may
cause clouding of the cornea. Ingestion may cause gastrointestinal irritation;
large doses given to animals resulted in collapse and coma.
This product contains material of human origin and should be considered as
potentially capable of transmitting infectious diseases.
Potential Effects of Chronic
Exposure
Frequent or long-term eye and skin exposure to ProClin 300 may
result in conjunctivitis and dermatitis.
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Section 11 Toxicological Information
(Continued)
Symptoms of Overexposure
Symptoms may include: coughing, headache, fatigue, nausea, vomiting, dizziness,
blurred vision, red and watery eyes, abdominal pain and unconsciousness.
Carcinogenicity
No ingredients in this product are listed as carcinogens by ACGIH,
IARC, NTP, OSHA or 67/548/EEC Annex I.
Other Effects
None identied.
Conditions Aggravated
by Exposure
None identied.
Section 12 Ecological Information
Ecotoxicity
No information available.
Biodegradability
No information available.
Bioaccumulation
No information available.
Mobility
No information available.
Other Adverse Effects
No information available.
Section 13 Disposal Considerations
Waste Disposal
Dispose of waste product, unused product and contaminated packaging in
compliance with federal, state and local regulations. If unsure of the applicable
requirements, contact the authorities for information.
Sodium azide preservative may form explosive compounds in metal drain lines.
See NIOSH Bulletin: Explosive Azide Hazard (8/16/76).
Section 14 Transport Information
Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.
Section 15 Regulatory Information
US Federal and State Regulations
SARA 313
Methanol is subject to reporting requirements of Section 313, Title III of SARA.
Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA.
CERCLA RG's,
40 CFR 302.4
Edetic Acid is listed.
Methanol is listed.
Sodium Azide is listed.
California Proposition 65
No ingredients listed.
Massachusetts MSL
Edetic Acid is listed.
Methanol is listed.
Sodium Azide is listed.
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Section 15 Regulatory Information
(Continued)
New Jersey Dept. of
Health RTK List
Edetic Acid is listed.
Methanol is listed.
Sodium Azide is listed.
Pennsylvania RTK
Edetic Acid is listed.
Methanol is listed.
Sodium Azide is listed.
Dipropylene Glycol is listed.
EU Labeling Classication
Classication
Irritant
Risk and Safety Phrases
R43
May cause sensitization by skin contact.
S28 After contact with skin, wash immediately with plenty of soap and water.
S37
Wear suitable gloves.
Canada
This product is exempt from WHMIS label and MSDS requirements.
PIN:
Not applicable
Ingredients on Ingredient
Disclosure List:
Methanol
Sodium Azide
Ingredients with unknown
toxicological properties:
Product is exempt
Some hazardous ingredients listed in Section 15 are below OSHAs and WHMIS' 1.0% w/w (0.1% for carcinogens)
or EU's ingredient specic concentrations required for reporting in Section 3.
Section 16 Other Information
Beckman Coulter Safety
Rating
Flammability (Section V): 0
Health (Section XI): 2
Reactivity with Water (Section X): 0
Contact (Section VIII): 2
Code
0=none
1=slight
2=caution
3=severe
Revision Changes
Reformatted Sections 2, 3, 5, 8, 9, 12, 15, and 16 per ANSI Z400.1-2004 Standard.
Risk Phrases and
WHMIS Classication
Description From
Section 3
R23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
R34
Causes burns.
R43
May cause sensitization by skin contact.
R50
Very toxic to aquatic organisms.
R53
May cause long-term adverse effects in the aquatic environment.
D2B - Sensitizer - Skin
D2B - Skin Or Eye Irritant
* ProClin is a trademark of the Rohm and Haas Company.
For further information, please contact your local Beckman Coulter representative.
WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO
WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE
RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS
MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.
CORTISOL CALIBRATORS
S0, S1, S2, S3, S4, S5
Doc. ID: 33605-75 AB