ÿþPage 1 of 12 @Beckman CoulterTM Kit MSDS Doc. ID: 33020-75: Rev. AB Product Information Product Name FERRITIN Part Number 33020 Doc. ID 33020-75 AB Issued (year/month/day) Revised (year/month/day) 2003/03/11 Series Name: ACCESSèø Components Description FERRITIN (Compartment R1a) FERRITIN (Compartment R1b) Transport Information Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG. éø2003 Beckman Coulter, Inc. Global MSDS  English Page 2 of 12 @Beckman CoulterTM MATERIAL SAFETY DATA SHEET Section 1 Company and Product Identification Product Name FERRITIN (Compartment R1a) Part Number Component of P/N 33020 FERRITIN Doc. ID 33020-75 AB Issued (year/month/day) Revised (year/month/day) 2003/03/11 Series Name ACCESSèø Manufacturer Beckman Coulter, Inc. 4300 Harbor Blvd. Fullerton, CA 92834-3100, U.S.A. Distributor and Emergency Phone No.  Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers. Section 2 Composition and Information on Ingredients Hazardous Ingredients: Meets Hazardous Criteria: Chemical Name CAS # % by wt. EU US OSHA WHMIS Tris(hydroxymethyl)aminomethane 77-86-1 >1 No Yes Exempt See Section 15 Regulatory Information for additional information on hazard classifications. Section 3 Hazards Identification Emergency Overview Reddish-brown; Opaque; Liquid; Mild odor Nonflammable aqueous solution. Skin, eye and respiratory tract irritant. Contains material of animal origin. Physical Hazards Sodium azide forms explosive compounds with heavy metals. This product contains concentrations of azide <0.1% (w/w) which with repeated contact with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. Potential Health Effects Summary Exposure may result in irritation of skin, eyes, and mucous membranes. See Section 11 Toxicological Information for more detailed health information. Product Hazard Classifications EU: Not applicable WHMIS: Exempt US OSHA: Hazardous Beckman Coulter Safety Rating Flammability (Section V): 0 Health (Section XI): 1 Reactivity with Water (Section X): 0 Contact (Section VIII): 2 Code 0=none 1=slight 2=caution 3=severe FERRITIN Doc. ID: 33020-75 AB Page 3 of 12 FERRITIN (Compartment R1a) Section 4 First Aid Measures Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or longer, making sure that the eyelids are held open. If pain or irritation occur, obtain medical attention. Skin Contact Remove any contaminated clothing. Wash affected area with plenty of soap and water. Use disinfectant if possible. Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical attention. Section 5 Fire Fighting Measures Flash Point Not applicable Flammable Limits Not applicable Autoignition Temp. Not applicable Extinguishing Media Use extinguishing media suitable for surrounding fire. Special Fire and Explosion Hazards None identified. Hazardous Combustion Products No combustion products posing significant hazards are expected from this product (a dilute aqueous solution). Protective Equipment for Firefighters Self-contained breathing apparatus is recommended for firefighters. Section 6 Accidental Release Measures Personal Precautions This product contains a material of biological origin. Use universal precautions during clean up procedures. Spill and Leak Procedures As a precautionary measure, treat spilled material with a 1:10 bleach/water solution. Absorb liquid and place in container suitable for disposal. Avoid generation of aerosols during clean up. Comply with applicable waste disposal regulations. Environmental Precautions Contain spill to prevent migration. Section 7 Handling and Storage Handling Precautions This product should be handled as though capable of transmitting infectious diseases. Universal precautions should be followed when using this product. Recommended Storage Conditions Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling. Section 8 Exposure Controls and Personal Protection Exposure Limits US OSHA: None established ACGIH: None established FERRITIN Doc. ID: 33020-75 AB Page 4 of 12 FERRITIN (Compartment R1a) Section 8 Exposure Controls and Personal Protection (Continued) DFG MAK: None established Engineering Controls No special engineering controls are required. Use with good general ventilation. Respiratory Protection Under normal conditions, the use of this product should not require respiratory protection. Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact. Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin contact. Section 9 Physical and Chemical Properties Physical State Liquid Color Reddish-brown Transparency Opaque Odor Mild odor Odor Threshold Not applicable pH 8.0 Boiling Point Not available Melting Point Not available Specific Gravity 1.01 @20°C Vapor Pressure Not available Vapor Density Not available Evaporation Rate Not available Solubility Water Matrix is miscible Organic Not available Section 10 Stability and Reactivity Stability Stable under normal temperatures and pressures. Hazardous Incompatibilities Strong acids Strong bases Strong oxidizers Metals and metallic compounds Sodium azide forms explosive compounds with heavy metals. This product contains concentrations of azide <0.1% (w/w) which with repeated contact with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. Hazardous Decomposition Products When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Conditions to Avoid Keep away from incompatible material. FERRITIN Doc. ID: 33020-75 AB Page 5 of 12 FERRITIN (Compartment R1a) Section 11 Toxicological Information Toxicity Data for Hazardous Ingredients Tris(hydroxymethyl)- aminomethane Oral LD50 Rat: 5900 mg/kg Primary Routes of Exposure Common routes of entry include inhalation, ingestion and eye/skin contact. Specific paths of concern for potentially infectious materials are skin puncture, contact with broken skin, contact with mucous membranes and inhalation of aerosolized material. Potential Effects of Acute Exposure Exposure to TRIS may result in irritation of skin, eyes and mucous membrane. Eye contact may result in redness, pain and corneal injury. Inhalation may result in chest pain and tightness, coughing, and difficult breathing. Ingestion may cause gastrointestinal irritation with burns to mouth and stomach, and large doses may cause weakness, collapse and death in laboratory animals. This product contains material of animal origin and should be considered as potentially capable of transmitting infectious diseases. Potential Effects of Chronic Exposure Prolonged or repeated exposure to TRIS by skin contact may result in dermatitis. Eye contact may cause conjunctivitis. Symptoms of Overexposure Symptoms of overexposure may include: throat irritation and coughing; dry, red, cracked skin; red irritated eyes; headache, drowsiness, dizziness, stupor; convulsions and coma. Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Other Effects None identified. Conditions Aggravated by Exposure None identified. Section 12 Ecological Information Ecotoxicity Toxic to fish and other water organisms. Biodegradability No information available. Mobility No information available. Section 13 Disposal Considerations Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Sodium azide preservative may form explosive compounds in metal drain lines. See NIOSH Bulletin: Explosive Azide Hazard (8/16/76). Section 14 Transport Information Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG. FERRITIN Doc. ID: 33020-75 AB Page 6 of 12 FERRITIN (Compartment R1a) Section 15 Regulatory Information US Federal and State Regulations SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA. Zinc Chloride is subject to reporting requirements of Section 313, Title III of SARA. CERCLA RG s, 40 CFR 302.4 Edetic Acid is listed. Sodium Phosphate, Dibasic is listed. Zinc Chloride is listed. Sodium Azide is listed. California Proposition 65 Gentamicin Sulfate has been identified by the State of California to cause reproductive harm. The State of California has adopted a regulation which requires a warning be given to individuals who may be exposed to chemicals identified by the State to cause cancer or reproductive harm. Accordingly, Beckman Coulter advises you of the following warning: WARNING: This product contains a chemical known to the State of California to cause reproductive harm. Massachusetts MSL Edetic Acid is listed. Sodium Phosphate, Dibasic is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. New Jersey Dept. of Health RTK List Edetic Acid is listed. Sodium Phosphate, Dibasic is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. Pennsylvania RTK Edetic Acid is listed. Sodium Phosphate, Dibasic is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. Florida Substance List Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. EU Labeling Classification Preparation not classified. Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Not applicable Ingredients on Ingredient Disclosure List: Zinc Chloride Sodium Azide Ingredients with unknown toxicological properties: Product is exempt Section 16 Other Information For further information, please contact your local Beckman Coulter representative. WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANYWAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A. Page 7 of 12 @Beckman CoulterTM MATERIAL SAFETY DATA SHEET Section 1 Company and Product Identification Product Name FERRITIN (Compartment R1b) Part Number Component of P/N 33020 FERRITIN Doc. ID 33020-75 AB Issued (year/month/day) Revised (year/month/day) 2003/03/11 Series Name ACCESSèø Manufacturer Beckman Coulter, Inc. 4300 Harbor Blvd. Fullerton, CA 92834-3100, U.S.A. Distributor and Emergency Phone No.  Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers. Section 2 Composition and Information on Ingredients Hazardous Ingredients: Meets Hazardous Criteria: Chemical Name CAS # % by wt. EU US OSHA WHMIS Tris(hydroxymethyl)aminomethane 77-86-1 >1 No Yes Exempt See Section 15 Regulatory Information for additional information on hazard classifications. Section 3 Hazards Identification Emergency Overview Colorless; Translucent; Liquid; Musty Nonflammable aqueous solution. Skin, eye and respiratory tract irritant. Contains material of animal origin. Physical Hazards Sodium azide forms explosive compounds with heavy metals. This product contains concentrations of azide <0.1% (w/w) which with repeated contact with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. Potential Health Effects Summary Exposure may result in irritation of skin, eyes, and mucous membranes. See Section 11 Toxicological Information for more detailed health information. Product Hazard Classifications EU: Not applicable WHMIS: Exempt US OSHA: Hazardous Beckman Coulter Safety Rating Flammability (Section V): 0 Health (Section XI): 1 Reactivity with Water (Section X): 0 Contact (Section VIII): 2 Code 0=none 1=slight 2=caution 3=severe FERRITIN Doc. ID: 33020-75 AB Page 8 of 12 FERRITIN (Compartment R1b) Section 4 First Aid Measures Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. Eye Contact If product enters eyes, wash eyes gently under running water for 15 minutes or longer, making sure that the eyelids are held open. If pain or irritation occur, obtain medical attention. Skin Contact Remove any contaminated clothing. Wash affected area with plenty of soap and water. Use disinfectant if possible. Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical attention. Section 5 Fire Fighting Measures Flash Point Not applicable Flammable Limits Not applicable Autoignition Temp. Not applicable Extinguishing Media Use extinguishing media suitable for surrounding fire. Special Fire and Explosion Hazards Combustion products may contain minute amounts of mercury. Hazardous Combustion Products No combustion products posing significant hazards are expected from this product (a dilute aqueous solution). Protective Equipment for Firefighters Self-contained breathing apparatus is recommended for firefighters. Section 6 Accidental Release Measures Personal Precautions This product contains a material of biological origin. Use universal precautions during clean up procedures. Spill and Leak Procedures As a precautionary measure, treat spilled material with a 1:10 bleach/water solution. Absorb liquid and place in container suitable for disposal. Avoid generation of aerosols during clean up. Comply with applicable waste disposal regulations. Environmental Precautions Contain spill to prevent migration. Section 7 Handling and Storage Handling Precautions This product should be handled as though capable of transmitting infectious diseases. Universal precautions should be followed when using this product. Recommended Storage Conditions Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling. Section 8 Exposure Controls and Personal Protection Exposure Limits US OSHA: None established ACGIH: None established FERRITIN Doc. ID: 33020-75 AB Page 9 of 12 FERRITIN (Compartment R1b) Section 8 Exposure Controls and Personal Protection (Continued) DFG MAK: None established Engineering Controls No special engineering controls are required. Use with good general ventilation. Respiratory Protection Under normal conditions, the use of this product should not require respiratory protection. Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact. Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin contact. Section 9 Physical and Chemical Properties Physical State Liquid Color Colorless Transparency Translucent Odor Musty Odor Threshold Not applicable pH 8.0 Boiling Point Not available Melting Point Not available Specific Gravity 1.01 @20°C Vapor Pressure Not available Vapor Density Not available Evaporation Rate Not available Solubility Water Miscible Organic Not available Section 10 Stability and Reactivity Stability Stable under normal temperatures and pressures. Hazardous Incompatibilities Strong acids Strong bases Strong oxidizers Metals and metallic compounds Sodium azide forms explosive compounds with heavy metals. This product contains concentrations of azide <0.1% (w/w) which with repeated contact with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. Hazardous Decomposition Products When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Conditions to Avoid Keep away from incompatible material. FERRITIN Doc. ID: 33020-75 AB Page 10 of 12 FERRITIN (Compartment R1b) Section 11 Toxicological Information Toxicity Data for Hazardous Ingredients Tris(hydroxymethyl)- aminomethane Oral LD50 Rat: 5900 mg/kg Primary Routes of Exposure Common routes of entry include inhalation, ingestion and eye/skin contact. Specific paths of concern for potentially infectious materials are skin puncture, contact with broken skin, contact with mucous membranes and inhalation of aerosolized material. Potential Effects of Acute Exposure Exposure to TRIS may result in irritation of skin, eyes and mucous membrane. Eye contact may result in redness, pain and corneal injury. Inhalation may result in chest pain and tightness, coughing, and difficult breathing. Ingestion may cause gastrointestinal irritation with burns to mouth and stomach, and large doses may cause weakness, collapse and death in laboratory animals. This product contains material of animal origin and should be considered as potentially capable of transmitting infectious diseases. Potential Effects of Chronic Exposure Prolonged or repeated exposure to TRIS by skin contact may result in dermatitis. Eye contact may cause conjunctivitis. Symptoms of Overexposure Symptoms of overexposure may include: throat irritation and coughing; dry, red, cracked skin; red irritated eyes; headache, drowsiness, dizziness, stupor; convulsions and coma. Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Other Effects None identified. Conditions Aggravated by Exposure None identified. Section 12 Ecological Information Ecotoxicity Toxic to fish and other water organisms. Biodegradability No information available. Mobility No information available. Section 13 Disposal Considerations Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Sodium azide preservative may form explosive compounds in metal drain lines. See NIOSH Bulletin: Explosive Azide Hazard (8/16/76). This product contains a low level (<0.05%) of Thimerosal. Specific federal, state, and local regulations for disposal of mercury compounds may apply. Section 14 Transport Information Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG. FERRITIN Doc. ID: 33020-75 AB Page 11 of 12 FERRITIN (Compartment R1b) Section 15 Regulatory Information US Federal and State Regulations SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA. Thimerosal is subject to reporting requirements of Section 313, Title III of SARA. Zinc Chloride is subject to reporting requirements of Section 313, Title III of SARA. CERCLA RG s, 40 CFR 302.4 Acetic Acid is listed. Sodium Phosphate, Dibasic is listed. Zinc Chloride is listed. Sodium Azide is listed. Thimerosal is listed. California Proposition 65 Thimerosal has been identified by the State of California to cause reproductive harm. The State of California has adopted a regulation which requires a warning be given to individuals who may be exposed to chemicals identified by the State to cause cancer or reproductive harm. Accordingly, Beckman Coulter advises you of the following warning: WARNING: This product contains a chemical known to the State of California to cause reproductive harm. Massachusetts MSL Acetic Acid is listed. Sodium Phosphate, Dibasic is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. Magnesium Chloride, Hexahydrate is listed. New Jersey Dept. of Health RTK List Acetic Acid is listed. Sodium Phosphate, Dibasic is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. Magnesium Chloride, Hexahydrate is listed. Pennsylvania RTK Acetic Acid is listed. Sodium Phosphate, Dibasic is listed. Zinc Chloride is listed. Sodium Azide is listed. Thimerosal is listed. Magnesium Chloride is listed. Magnesium Chloride, Hexahydrate is listed. Florida Substance List Acetic Acid is listed. Zinc Chloride is listed. Sodium Azide is listed. Magnesium Chloride is listed. Magnesium Chloride, Hexahydrate is listed. EU Labeling Classification Preparation not classified. FERRITIN Doc. ID: 33020-75 AB Page 12 of 12 FERRITIN (Compartment R1b) Section 15 Regulatory Information (Continued) Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Not applicable Ingredients on Ingredient Disclosure List: Thimerosal Acetic Acid Zinc Chloride Sodium Azide Ingredients with unknown toxicological properties: Product is exempt Section 16 Other Information For further information, please contact your local Beckman Coulter representative. WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANYWAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.