ÿþPage 1 of 5 @Beckman Coulter® MATERIAL SAFETY DATA SHEET Section 1 Company and Product Identification Product Name SUBSTRATE Part Number 81906 Doc. ID 81906-75 AB Issued (year/month/day) Revised (year/month/day) 2004/07/08 Product Use For In Vitro Diagnostic Use. See product literature for details. Series Name ACCESSèø Manufacturer Beckman Coulter, Inc. 4300 Harbor Blvd. Fullerton, CA 92835-3100, U.S.A. Distributor and Emergency Phone No.  Refer to attached list, Document ID: 472050, for local distributor and emergency phone numbers. Section 2 Composition and Information on Ingredients Hazardous Ingredients: Meets Hazardous Criteria: Chemical Name CAS # % by wt. EU US OSHA WHMIS 2-Amino-2-methyl-1-propanol 124-68-5 <10% No Yes Exempt See Section 15 Regulatory Information for additional information on hazard classifications. Section 3 Hazards Identification Emergency Overview Fluorescent yellow; Translucent; Liquid; Slight amine odor Nonflammable aqueous solution. Skin, eye, respiratory, and gastrointestinal irritant. Physical Hazards No physical hazards were determined from a review of available literature. Potential Health Effects Summary Exposure may result in irritation of skin, eyes, and mucous membranes. See Section 11 Toxicological Information for more detailed health information. Product Hazard Classifications EU: Not applicable WHMIS: Exempt US OSHA: Hazardous Beckman Coulter Safety Rating Flammability (Section V): 0 Health (Section XI): 1 Reactivity with Water (Section X): 0 Contact (Section VIII): 2 Code 0=none 1=slight 2=caution 3=severe Section 4 First Aid Measures Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. éø2004 Beckman Coulter, Inc. Global MSDS  English SUBSTRATE MSDS # 81906-75 AB Page 2 of 5 Section 4 First Aid Measures (Continued) Eye Contact If product is splashed in eyes, wash eyes under gently running water for several minutes, making sure that the eyelids are held open. If irritation or redness develops, obtain medical attention. Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. If pain or irritation occur, obtain medical attention. Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical attention. Section 5 Fire Fighting Measures Flash Point Not applicable Flammable Limits Not available Autoignition Temp. Not applicable Extinguishing Media Use extinguishing media suitable for surrounding fire. Special Fire and Explosion Hazards No special hazards determined. Hazardous Combustion Products Due to the composition and volume of this product, combustion products generated from it are not expected to present a significant hazard. Protective Equipment for Firefighters Self-contained breathing apparatus is recommended for firefighters. Section 6 Accidental Release Measures Personal Precautions No special precautions are necessary. Use good laboratory procedures. Spill and Leak Procedures Absorb spilled material with an appropriate inert, non-flammable absorbent and dispose according to local regulations. Environmental Precautions Contain spill to prevent migration. Section 7 Handling and Storage Handling Precautions Use good laboratory procedures; avoid eye and skin contact. Recommended Storage Conditions Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling. Section 8 Exposure Controls and Personal Protection Exposure Limits US OSHA: None established ACGIH: None established DFG MAK: None established Engineering Controls No special engineering controls are required. Use with good general ventilation. SUBSTRATE MSDS # 81906-75 AB Page 3 of 5 Section 8 Exposure Controls and Personal Protection (Continued) Respiratory Protection Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact. Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin contact. Section 9 Physical and Chemical Properties Physical State Liquid Color Fluorescent yellow Transparency Translucent Odor Slight amine odor Odor Threshold Not applicable pH 9.6 Boiling Point Not available Melting Point Not available Specific Gravity 1.007 @20°C Vapor Pressure Not available Vapor Density Not available Evaporation Rate Not available Solubility Water Miscible Organic Not available Section 10 Stability and Reactivity Stability Stable under normal temperatures and pressures. Hazardous Incompatibilities Strong oxidizers Strong acids Hazardous Decomposition Products When stored as labeled, no known hazardous decomposition products are formed during the shelf-life of this product. Conditions to Avoid Keep away from incompatible material. Section 11 Toxicological Information Toxicity Data for Hazardous Ingredients 2-Amino-2-methyl-1-propanol Oral LD50 Rat: 2900 mg/kg; Oral LD50 Mouse: 2150 mg/kg Primary Routes of Exposure The most likely routes of exposure are skin, eye contact and inhalation; material may be absorbed through the skin. SUBSTRATE MSDS # 81906-75 AB Page 4 of 5 Section 11 Toxicological Information (Continued) Potential Effects of Acute Exposure May cause irritation of nose, skin, and eyes. Additional effects may include headache, nausea, and vomiting. Potential Effects of Chronic Exposure Frequent or long-term exposure may result in conjunctivitis and dermatitis. Symptoms of Overexposure Symptoms of overexposure may include: irritation of nose, skin and eyes, burning sensation of mucous membranes, headache, nausea and vomiting. Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Other Effects None identified. Conditions Aggravated by Exposure None identified. Section 12 Ecological Information Ecotoxicity Toxic to fish and other water organisms. Biodegradability No information available. Mobility No information available. Section 13 Disposal Considerations Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Section 14 Transport Information Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG. Section 15 Regulatory Information US Federal and State Regulations SARA 313 No ingredients listed CERCLA RG s, 40 CFR 302.4 No ingredients listed California Proposition 65 No ingredients listed Massachusetts MSL 2-Amino-2-methyl-1-propanol is listed. Magnesium Chloride is listed. New Jersey Dept. of Health RTK List Magnesium Chloride is listed. Pennsylvania RTK 2-Amino-2-methyl-1-propanol is listed. Magnesium Chloride is listed. EU Labeling Classification Preparation not classified. SUBSTRATE MSDS # 81906-75 AB Page 5 of 5 Section 15 Regulatory Information (Continued) Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Not applicable Ingredients on Ingredient Disclosure List: None Ingredients with unknown toxicological properties: Product is exempt Section 16 Other Information For further information, please contact your local Beckman Coulter representative. WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANYWAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.