Page1of11 @ Beckma n CoulterTM Kit MSDS Doc. ID:445980­75: Rev. AB ProductInformation ProductName BenzodiazepineReagent Part Number 445980 Doc. ID 445980­75 AB Issued (day/month/year) 13/04/1999 Series Name: SYNCHRONSystems Components Description Benzodiazepine Reagent (Compartment A) Benzodiazepine Reagent (Compartment B) TransportInformation Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG. ª1999 Beckman Coulter, Inc. Global MSDS – English = Page 1 = Page2of11 @ Beckma n CoulterTM MATERIAL SAFETY DATA SHEET Section1CompanyandProductIdentification ProductName Benzodiazepine Reagent (CompartmentA) Part Number Component of P/N 445980 Benzodiazepine Reagent Doc. ID 445980­75 AB Issued (day/month/year) 13/04/1999 Series Name SYNCHRONSystems Manufacturer Beckman Coulter, Inc. 4300 Harbor Blvd. Fullerton, CA 92834­3100, U.S.A. Distributor and Emergency Phone No. % Refer to attached list, Document ID:472050, for local distributor and emergency phone numbers. Section2 Composition andInformationonIngredients HazardousIngredients: None Section3HazardsIdentification Emergency Overview Colorless; Transparent; Liquid; Odorless Nonflammable aqueous solution. Containsanimalmaterial whichmay havecomein contactwithhuman material. Does not meet EU, OSHA or WHMIS criteria for hazardous materials. Physical Hazards No physical hazards were determined from a review of available literature. Potential Health Effects Summary This product does not meet EU, OSHA or WHMIS criteria for hazardous materials. However, it does contain animal material which may have come in contact with human material during processing and should be considered potentially infectious. Product Hazard Classifications EU: Not applicable WHMIS: Exempt US OSHA: Not applicable Section4FirstAid Measures Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. Eye Contact If product is splashed in eyes, wash eyes under gently running water for 15 minutes or longer, making sure that the eyelids are held open. Obtain medical attention. = Page 2 = Benzodiazepine Reagent Doc. ID: 445980­75 AB Page3of11 Benzodiazepine Reagent (Compartment A) 445980­75 AB Section4First AidMeasures(Continued) Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes. Then gently wash skin with soap and water; rinse well. If product contacted broken skin, soak the wound area with a 1:10 dilution of fresh household bleach for 10 minutes. Rinse with water to remove residual bleach. (Remove contaminated clothing and disinfect with a 1:10 dilution of fresh household bleach.) Obtain medical attention. Ingestion If ingested, wash out mouth with water. Call a physician. Section5FireFighting Measures Flash Point Not applicable FlammableLimits Not applicable AutoignitionTemp. Not applicable Extinguishing Media Use extinguishing media suitable for surrounding fire. Special Fire and Explosion Hazards No special hazards determined. Hazardous Combustion Products Due to the nature and volume of this product, the type and amount of combustion products are negligible. Protective Equipment for Firefighters Self­contained breathing apparatus is recommended for firefighters. Section6AccidentialReleaseMeasures Personal Precautions Use universal precautions during clean up procedures. Spill and Leak Procedures As a precautionary measure, treat spilled material with a 1:10 bleach/water solution. Absorb liquid and place in container suitable for disposal. Avoid generation of aerosols during clean up. Comply with applicable waste disposal regulations. Environmental Precautions Contain spill to prevent migration. Section7Handling andStorage Handling Precautions This product should be handled as though capable of transmitting infectious diseases. Universal precautions should be followed when using this product. Recommended Storage Conditions Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling. Section8ExposureControlsandPersonalProtection Exposure Limits US OSHA: None established ACGIH: None established DFG MAK: None established = Page 3 = Benzodiazepine Reagent Doc. ID: 445980­75 AB Page4of11 Benzodiazepine Reagent (Compartment A) 445980­75 AB Section8ExposureControlsandPersonalProtection(Continued) Engineering Controls Use in well ventilated area. Respiratory Protection Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact. Skin Protection Impervious gloves, such as latex or equivalent, should be worn to prevent skin contact. Section9PhysicalandChemicalProperties Physical State Liquid Color Colorless Transparency Transparent Odor Odorless Odor Threshold Not applicable pH 5 Boiling Point Not available Melting Point Not available Specific Gravity 1@20 C Vapor Pressure Not available Vapor Density Not available Evaporation Rate Not available Coefficient of Water/Oil Distribution Not available Percent Volatiles Not applicable Solubility Water Miscible Organic Not available Section10StabilityandReactivity Stability Stable under normal temperatures and pressures. Hazardous Incompatibilities Metals and metallic compounds Sodium azide forms explosive compounds with heavy metals. Repeated contact of low concentrations of azide with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. Hazardous Decomposition Products When stored as labeled, no known hazardous decomposition products are formed during the shelf­life of this product. Conditions to Avoid Keep away from incompatible material. = Page 4 = Benzodiazepine Reagent Doc. ID: 445980­75 AB Page5of11 Benzodiazepine Reagent (Compartment A) 445980­75 AB Section11ToxicologicalInformation Toxicity Data for Hazardous Ingredients Not applicable Primary Routes of Exposure Common routes of entry include inhalation, ingestion and eye/skin contact. Specific paths of concern for potentially infectious materials are skin puncture, contact with broken skin, contact with mucous membranes and inhalation of aerosolized material. Potential Effects of Acute Exposure This product contains materials of animal origin, some of which may have come into contact with human material during processing. The product should be considered as potentially capable of transmitting infectious diseases. Potential Effects of Chronic Exposure Effects are similar to those for acute exposure. Symptoms of Overexposure No specific symptoms identified. Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Other Effects None identified. Conditions Aggravated by Exposure None identified. Section12EcologicalInformation Ecotoxicity No information available. Biodegradability No information available. Mobility No information available. Section13DisposalConsiderations Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Sodium azide preservative may form explosive compounds in metal drain lines. See NIOSH Bulletin: Explosive Azide Hazard (8/16/76). Section14TransportInformation Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG. Section15RegulatoryInformation US Federal and State Regulations SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA. CERCLA RG’s, 40 CFR 302.4 Sodium Azide is listed. California Proposition 65 No ingredients listed = Page 5 = Benzodiazepine Reagent Doc. ID: 445980­75 AB Page6of11 Benzodiazepine Reagent (Compartment A) 445980­75 AB Section15 Regulatory Information(Continued) US Federal and State Regulations Massachusetts MSL Sodium Azide is listed. New Jersey Dept. of Health RTK List Sodium Azide is listed. Pennsylvania RTK Sodium Azide is listed. EU Dangerous Ingredients None Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Not applicable Ingredients on Ingredient Disclosure List: Sodium Azide Ingredients with unknown toxicological properties: Product is exempt Section16OtherInformation For further information, please contact your local Beckman Coulter representative. WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A. = Page 6 = Page7of11 @ Beckma n CoulterTM MATERIAL SAFETY DATA SHEET Section1CompanyandProductIdentification ProductName Benzodiazepine Reagent (CompartmentB) Part Number Component of P/N 445980 Benzodiazepine Reagent Doc. ID 445980­75 AB Issued (day/month/year) 13/04/1999 Series Name SYNCHRONSystems Manufacturer Beckman Coulter, Inc. 4300 Harbor Blvd. Fullerton, CA 92834­3100, U.S.A. Distributor and Emergency Phone No. % Refer to attached list, Document ID:472050, for local distributor and emergency phone numbers. Section2 Composition andInformationonIngredients HazardousIngredients: None Section3HazardsIdentification Emergency Overview Colorless; Transparent; Liquid; Odorless Nonflammable aqueous solution. Does not meet EU, OSHA or WHMIS criteria for hazardous materials. Physical Hazards No physical hazards were determined from a review of available literature. Potential Health Effects Summary This product does not meet EU, OSHA or WHMIS criteria for hazardous materials. Product Hazard Classifications EU: Not applicable WHMIS: Exempt US OSHA: Not applicable Section4FirstAid Measures Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. Eye Contact If product is splashed in eyes, wash eyes under gently running water for several minutes, making sure that the eyelids are held open. If irritation or redness develops, obtain medical attention. Skin Contact In case of skin contact, wash area with soap and water. Rinse well with water. Ingestion If ingested, wash out mouth with water. Call a physician. = Page 7 = Benzodiazepine Reagent Doc. ID: 445980­75 AB Page8of11 Benzodiazepine Reagent (Compartment B) 445980­75 AB Section5FireFighting Measures Flash Point Not applicable FlammableLimits Not applicable AutoignitionTemp. Not applicable Extinguishing Media Use extinguishing media suitable for surrounding fire. Special Fire and Explosion Hazards No special hazards determined. Hazardous Combustion Products Due to the nature and volume of this product, the type and amount of combustion products are negligible. Protective Equipment for Firefighters Self­contained breathing apparatus is recommended for firefighters. Section6AccidentialReleaseMeasures Personal Precautions Avoid skin contact. Use good laboratory procedures. Spill and Leak Procedures Wipe up material carefully and place in container suitable for disposal. Environmental Precautions Contain spill to prevent migration. Section7Handling andStorage Handling Precautions Use good laboratory procedures; avoid eye and skin contact. Recommended Storage Conditions Keep away from incompatible material. To maintain efficacy, store according to the instructions in the product labeling. Section8ExposureControlsandPersonalProtection Exposure Limits US OSHA: None established ACGIH: None established DFG MAK: None established Engineering Controls Use in well ventilated area. Respiratory Protection Under normal conditions, the use of this product should not require respiratory protection. If overexposure should occur and ventilation is not adequate to maintain airborne concentrations at acceptable levels, the use of respiratory protection should be evaluated by a qualified professional. Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact. Skin Protection Impervious gloves should be worn to prevent skin contact. Section9PhysicalandChemicalProperties Physical State Liquid = Page 8 = Benzodiazepine Reagent Doc. ID: 445980­75 AB Page9of11 Benzodiazepine Reagent (Compartment B) 445980­75 AB Section9PhysicalandChemicalProperties(Continued) Color Colorless Transparency Transparent Odor Odorless Odor Threshold Not applicable pH 8 Boiling Point Not available Melting Point Not available Specific Gravity 1@20 C Vapor Pressure Not available Vapor Density Not available Evaporation Rate Not available Coefficient of Water/Oil Distribution Not available Percent Volatiles Not applicable Solubility Water Miscible Organic Not available Section10StabilityandReactivity Stability Stable under normal temperatures and pressures. Hazardous Incompatibilities Sodium azide forms explosive compounds with heavy metals. Repeated contact of low concentrations of azide with lead and copper commonly found in plumbing drains may result in the build up of shock sensitive compounds. Metals and metallic compounds Hazardous Decomposition Products When stored as labeled, no known hazardous decomposition products are formed during the shelf­life of this product. Conditions to Avoid Keep away from incompatible material. Section11ToxicologicalInformation Toxicity Data for Hazardous Ingredients Not applicable Primary Routes of Exposure The most likely routes of exposure are skin and eye contact and inhalation. Potential Effects of Acute Exposure None identified. Potential Effects of Chronic Exposure None identified. Symptoms of Overexposure No specific symptoms identified. = Page 9 = Benzodiazepine Reagent Doc. ID: 445980­75 AB Page 10 of 11 Benzodiazepine Reagent (Compartment B) 445980­75 AB Section11ToxicologicalInformation (Continued) Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Other Effects None identified. Conditions Aggravated by Exposure None identified. Section12EcologicalInformation Ecotoxicity No information available. Biodegradability No information available. Mobility No information available. Section13DisposalConsiderations Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Sodium azide preservative may form explosive compounds in metal drain lines. See NIOSH Bulletin: Explosive Azide Hazard (8/16/76). Section14TransportInformation Transportation of this product is not regulated under ICAO, IATA, US DOT, European ADR or Canadian TDG. Section15RegulatoryInformation US Federal and State Regulations SARA 313 Sodium Azide is subject to reporting requirements of Section 313, Title III of SARA. CERCLA RG’s, 40 CFR 302.4 Sodium Azide is listed. California Proposition 65 No ingredients listed Massachusetts MSL Sodium Azide is listed. New Jersey Dept. of Health RTK List Sodium Azide is listed. Pennsylvania RTK Sodium Azide is listed. EU Dangerous Ingredients None = Page 10 = Benzodiazepine Reagent Doc. ID: 445980­75 AB Page 11 of 11 Benzodiazepine Reagent (Compartment B) 445980­75 AB Section15 Regulatory Information(Continued) Canada This product is exempt from WHMIS label and MSDS requirements. PIN: Not applicable Ingredients on Ingredient Disclosure List: Sodium Azide Ingredients with unknown toxicological properties: Product is exempt Section16OtherInformation For further information, please contact your local Beckman Coulter representative. WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A. = Page 11 =