MSDS – PreservCyt ® Solution
CYTYC P/N 85093-001 Rev. H. Page 1 of 5
For distribution by Cytyc US
1. CHEMICAL AND COMPANY IDENTIFICATION
Product Identification:
PreservCyt® Solution
Trade Name/Chemical Family/Synonyms:
Methanol-water solution
Product Description:
A methanol based, buffered preservative solution
Product Use:
A preservative solution to support cells during transport and slide preparation.
Manufacturer
Cytyc Corporation
250 Campus Drive
Marlborough, Massachusetts 01752
USA
Telephone: 800-442-9892
EMERGENCY TELEPHONE NUMBERS:
(24 hours a day and 7 days a week)
For Health/Transportation/Chemical Spills
(Multilingual capabilities and free calls accepted)
Continental United States: (800) 424-9300
Outside of continental United States: +(703) 527-3887
2. COMPOSITION/INFORMATION ON INGREDIENTS
Component CAS Registry # Wt. %
Methanol 67-56-1 30 – 60
Water 7782-13-5 40 – 70
3. HAZARDS IDENTIFICATION:
EMERGENCY
OVERVIEW:
Material is a clear flammable liquid. Inhalation of vapors may cause nonspecific discomfort
(nausea, weakness), drowsiness with anesthetic effects and possible blindness. Swallowing as
little as 4 ounces (118 ml) may cause blindness and in extreme cases death.
Potential Health Effects.
Inhalation:
May cause depression of central nervous system resulting in nausea, weakness, drowsiness and
possibly blindness.
Eye Contact:
May cause transient irritation.
Skin Contact:
May cause irritation and/or dermatitis. Material may be absorbed through the skin resulting in
effects similar to ingestion or inhalation.
Ingestion:
May cause intoxication, Central nervous system depression, nausea, and dizziness. May damage
liver, kidneys and nervous system. May cause blindness and/or death.
Target Organs:
Liver, kidneys, and central nervous system.
MSDS – PreservCyt ® Solution
CYTYC P/N 85093-001 Rev. H. Page 2 of 5
For distribution by Cytyc US
Medical Conditions
Aggravated by Exposure:
Individuals with preexisting diseases of the retina (eyes) or liver may have increased
susceptibility to toxicity at lower levels of successive exposure (repeated exposures).
Chronic:
Liquid and vapor can penetrate skin and mucous membranes. May cause chronic liver, kidney or
nervous system disorders.
4. FIRST AID MEASURES:
Inhalation:
Remove patient to fresh air. If symptoms of intoxication or vision problems are apparent, get
immediate medical aid.
Eye Contact:
Immediately flush with clean water for at least 15 minutes. Get medical aid.
Skin Contact:
Remove contaminated clothing and shoes. Flush affected area with copious amounts of water.
If irritation or other symptoms are present, get immediate medical assistance.
Ingestion:
Do Not Induce Vomiting. Give one or two glasses of water and get immediate medical aid.
Notes to Physician:
Treat for CNS depression and possible renal failure.
5. FIRE FIGHTING MEASURES:
Flashpoint and Method:
80ºF (26.5ºC) Closed cup
Autoignition Temperature:
725ºF (385ºC)
Flammable Limits:
LEL-6.7 UEL-36 (based on methanol component)
General Hazard:
Flammable material. Heated material may form toxic and/or explosive vapors.
Fire Fighting Instructions:
Wear full turnout gear with self-contained breathing apparatus. If material is not involved
in fire, attempt to cool with water or remove from area. FLAME INVISIBLE IN
DAYLIGHT.
Fire Fighting Equipment:
Wear full turnout gear with self-contained breathing apparatus.
Extinguishing Media:
Foam – Yes Alcohol Foam – Yes C02 – Yes Dry Chemical – Yes
Water – Yes Other – Water Fog
Hazardous Combustion Products:
Carbon Monoxide and Carbon Dioxide
NFPA Hazard Rating:
(National Fire Protection
Association)
Health – 1
Flammability – 3
Reactivity – 0
Special Information – None
0=Insignificant
1=Slight
2=Moderate
3=High
4=Extreme
U=Unknown *=No Information
Special Information:
None
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CYTYC P/N 85093-001 Rev. H. Page 3 of 5
For distribution by Cytyc US
6. ACCIDENTAL RELEASE MEASURES:
Land Spill
Prevent runoff from entering waterways. Dyke large spills with clay. Absorb small spills with clay or kitty
litter. For spills in excess of 50 gallons, contact licensed HAZWOPER responders.
Water Spill:
Follow local, state and Federal guidelines and regulations.
Follow Local, State, Provincial, and Federal Guidelines for all spills.
7. HANDLING AND STORAGE:
Handling:
KEEP OUT OF THE REACH OF CHILDREN. Wear recommended personal protective equipment and
avoid contact with skin and eyes.
Storage:
Store away from excessive heat and sources of ignition. Keep containers closed and protect from damage.
Storage Temperatures: Without cytologic sample: 59 – 86 ºF (15 – 30ºC)
With cytologic samples, for up to three weeks: 39 – 99 ºF (4 – 37ºC)
8. EXPOSURE CONTROLS / PERSONAL PROTECTIVE EQUIPMENT:
Engineering Controls:
Supply exhaust and/or ventilation to keep vapor levels below threshold limit value.
Respirator:
Where engineering controls are not adequate, use approved NIOSH respirators or supplied
air respirators.
Protective Clothing:
Chemically resistant gloves and eye protection.
Exposure Limits for Ingredients:
Ingredient OSHA PEL ACGIH TLV®
200 ppm – TWA 200 ppm – TWA
250 ppm – STEL
Skin
Canada – Alberta, British Columbia, New
Brunswick, Manitoba, Ontario,
Quebec, and Yukon
Canada – Saskatchewan
Methanol
TWA – 8 hr
STEL – 15 minute
200 ppm – TWA
250 ppm – STEL
Skin
262 mg/m3 TWA
328 mg/m3 STEL
9. PHYSICAL AND CHEMICAL PROPERTIES:
Vapor Pressure mm/Hg: 127 Appearance: clear, thin
Specific Gravity (Water=1): 0.92 Physical State: liquid
Solubility in Water: complete Vapor Density (Air=1): 1.1
Freezing Point (OF/OC): not established. Percent Volatile by Volume: > 99
Evaporation Rate (BuAc=1): > 1 pH: Not applicable
Viscosity: Not determined Odor: Alcohol type odor
Boiling Point (OF/OC): 148/64.5
MSDS – PreservCyt ® Solution
CYTYC P/N 85093-001 Rev. H. Page 4 of 5
For distribution by Cytyc US
10. STABILITY AND REACTIVITY:
General Stability:
Stable
Incompatible Materials And Conditions To Avoid:
Strong oxidizers. (May ignite product)
Hazardous Decomposition Products:
Carbon monoxide and carbon dioxide
Hazardous Polymerization:
Will not occur.
11. TOXICOLOGICAL INFORMATION:
For methanol: Product
not tested as a mixture:
Inhalation LC50 Rat: 64000 ppm/4H
Oral LD50 Rat: 5628 mg/kg
Oral LD50 Mouse: 7300 mg/kg
Dermal LD50 Rabbit: 15800 mg/kg
12. ECOLOGICAL INFORMATION:
Material has very low aquatic toxicity.
LC50 Pimephales promelas (fathead minnows) 29.4 g/l/96 hr, (28-29 days old)
EC50 (30 min) Photobacterium phosphoreum: 51,000-320,000 mg/L:
13. DISPOSAL CONSIDERATION:
RCRA Hazardous Waste if Discarded? Yes. If so, RCRA ID number: D001, Ignitable waste.
14. TRANSPORTATION INFORMATION: DOT (Department of Transportation)
US DOT
Proper Shipping Name: Flammable liquids, n.o.s. (Methanol)
Hazard Class: 3
Identification Number: UN1993
Packing Group: III
MSDS – PreservCyt ® Solution
CYTYC P/N 85093-001 Rev. H. Page 5 of 5
For distribution by Cytyc US
15. REGULATORY INFORMATION:
TSCA (Toxic Substances Control Act): All ingredients listed on TSCA inventory.
CERCLA:
RQ for methanol – 5,000 lbs. (2,268 kg) No TPQ established for methanol
SARA 311 Status:
Immediate, fire hazard
SARA 313:
Methanol is listed on the 313 Toxic Pollutant reporting list.
State Issues:
Not listed for California Proposition 65
Foreign Chemical Inventories:
All ingredients are listed on the chemical inventories of the following countries:
Canada (DSL)
Japan
European Union
Australia
WHMIS Status (Canada):
A controlled product. Classification: B2; D1B; D2A
This product has been classified in accordance with hazard criteria of the Controlled
Products Regulations and the MSDS contains all the information required by the Controlled
Products Regulations.
16. OTHER INFORMATION:
Current Issue Date: February, 2005
Previous Issue Date:
July, 2002
Changes to MSDS:
New format and revision of text to improve clarity. Addition of non-US exposure values.
Other Information:
None
Information Note: Where no corresponding data was contained in manufacturer’s MSDS, additional research is
required and available upon request. THE INFORMATION RELATES TO THIS SPECIFIC MATERIAL. IT MAY NOT BE
VALID FOR THIS MATERIAL IF USED IN COMBINATION WITH ANY OTHER MATERIALS OR IN ANY PROCESS. IT IS
THE USER’S RESPONSIBILITY TO SATISFY ONESELF AS TO THE SUITABILITY AND COMPLETENESS OF THIS
INFORMATION FOR HIS OR HER OWN PARTICULAR USE.