Material Safety Data Sheet Catalog Number: 153741 Revision date: 26-Apr-2006 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY INFORMATION Catalog Number: 153741 Product name: DEXTRORPHAN-D-TARTRATE Supplier: MP Biomedicals, LLC 29525 Fountain Parkway Solon, OH 44139 tel: 440-337-1200 Emergency telephone number: CHEMTREC: 1-800-424-9300 (1-703-527-3887) 2. COMPOSITION/INFORMATION ON INGREDIENTS Components CAS Number Weight % ACGIH Exposure Limits: OSHA Exposure Limits: DEXTRORPHAN-D-TARTRATE 125-73-5 90 - 100% None None 3. HAZARDS IDENTIFICATION EMERGENCY OVERVIEW: Harmful by inhalation, in contact with skin and if swallowed. Category of Danger: Harmful Principle routes of exposure: Skin Inhalation: Harmful by inhalation. Ingestion: Harmful if swallowed. Skin contact: Harmful in contact with skin. Eye contact: Risk of serious damage to eyes Statements of hazard HARMFUL IF SWALLOWED. MAY BE HARMFUL IF ABSORBED THROUGH SKIN OR INHALED. Statement of Spill or Leak - ANSI Label Eliminate all ignition sources. Absorb and/or contain spill with inert materials (e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush spill area. Prevent runoff from entering waterways or sewers. Statement of First Aid If swallowed, do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Call a physician. Precautions - ANSI Label Do not taste or swallow. Wash thoroughly after handling. 4. FIRST AID MEASURES General advice: In the case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Inhalation: Move to fresh air. Call a physician immediately. Skin contact: Rinse immediately with plenty of water and seek medical advice Product name: DEXTRORPHAN-D-TARTRATE Page 1 of 5 Catalog Number: 153741 www.mpbio.com MP Biomedicals, LLC Ingestion: Do not induce vomiting without medical advice. Never give anything by mouth to an unconscious person. Consult a physician Eye contact: In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Protection of first-aiders: No information available Medical conditions aggravated by exposure: None known 5. FIRE FIGHTING MEASURES Suitable extinguishing media: Use dry chemical, CO2, water spray or "alcohol" foam Specific hazards: Burning produces irritant fumes. Unusual hazards: None known Special protective equipment for firefighters: As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear Specific methods: Water mist may be used to cool closed containers. Flash point: Not determined Autoignition temperature: Not determined NFPA rating: NFPA Health: 0 NFPA Flammability: 0 NFPA Reactivity: 0 6. ACCIDENTAL RELEASE MEASURES Personal precautions: Use personal protective equipment. Environmental precautions: Prevent product from entering drains. Methods for cleaning up: Sweep up and shovel into suitable containers for disposal. 7. HANDLING AND STORAGE Storage: ROOM TEMPERATURE Handling: Use only in area provided with appropriate exhaust ventilation. Safe handling advice: Wear personal protective equipment. Technical measures/storage conditions: Keep containers tightly closed in a cool, well-ventilated place. Incompatible products: Oxidising and spontaneously flammable products 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering measures: Ensure adequate ventilation. PERSONAL PROTECTIVE EQUIPMENT Respiratory protection: Breathing apparatus only if aerosol or dust is formed. Hand protection: Pvc or other plastic material gloves Skin and body protection: Usual safety precautions while handling the product will provide adequate protection against this potential effect. Eye protection: Safety glasses with side-shields Hygiene measures: Handle in accordance with good industrial hygiene and safety practice. 9. PHYSICAL AND CHEMICAL PROPERTIES Product name: DEXTRORPHAN-D-TARTRATE Page 2 of 5 Catalog Number: 153741 www.mpbio.com MP Biomedicals, LLC Physical state: Powder Formula: C17H23NO • C4H6O6 Molecular weight: 407.47 Melting point/range: No data available at this time. Boiling point/range: No Data available at this time. Density: No data available Vapor pressure: No data available Evaporation rate: No data available Vapor density: No data available Solubility (in water): No data available Flash point: Not determined Autoignition temperature: Not determined 10. STABILITY AND REACTIVITY Stability: Stable under recommended storage conditions. Polymerization: None under normal processing. Hazardous decomposition products: Nitrogen oxides (NOx)/ammonia/CN- Materials to avoid: Strong oxidising agents Conditions to avoid: Exposure to air or moisture over prolonged periods. 11. TOXICOLOGICAL INFORMATION Product Information Acute toxicity Components RTECS Number: Selected LD50s and LC50s DEXTRORPHAN-D-TARTRATE QD1832000 Oral LD50 Rat : 584 mg/kg Oral LD50 Mouse : 276 mg/kg Chronic toxicity: Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness. Local effects: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting. Specific effects: May include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting, headache. Primary irritation: No data is available on the product itself. Carcinogenic effects: No data is available on the product itself. Mutagenic effects: No data is available on the product itself. Reproductive toxicity: No data is available on the product itself. 12. ECOLOGICAL INFORMATION Mobility: No data available Bioaccumulation: No data available Ecotoxicity effects: No data available Aquatic toxicity: May cause long-term adverse effects in the aquatic environment. Components U.S. DOT - Appendix B - Marine Pollutan U.S. DOT - Appendix B - Severe Marine Pollutants United Kingdom - The Red List: DEXTRORPHAN-D-TARTRATE Not Listed Not Listed Not Listed Components Germany VCI (WGK) World Health Organization (WHO) - Drinking Water Ecotoxicity - Fish Species Data DEXTRORPHAN-D-TARTRATE Not Listed Not Listed Not Listed Product name: DEXTRORPHAN-D-TARTRATE Page 3 of 5 Catalog Number: 153741 www.mpbio.com MP Biomedicals, LLC Components Ecotoxicity - Freshwater Algae Data Ecotoxicity - Microtox Data Ecotoxicity - Water Flea Data DEXTRORPHAN-D-TARTRATE Not Listed Not Listed Not Listed Components EPA - ATSDR Priority List EPA - HPV Challenge Program Chemical List California - Priority Toxic Pollutants DEXTRORPHAN-D-TARTRATE Not Listed Not Listed Not Listed Components California - Priority Toxic Pollutants California - Priority Toxic Pollutants DEXTRORPHAN-D-TARTRATE Not Listed Not Listed 13. DISPOSAL CONSIDERATIONS Waste from residues / unused products: Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This product, if unaltered by use, may be disposed of by treatment at a permitted facility or as advised by your local hazardous waste regulatory authority. Residue from fires extinguished with this material may be hazardous. Contaminated packaging: Do not re-use empty containers 14. TRANSPORT INFORMATION UN/Id No: Not regulated DOT: Proper shipping name: Not Regulated Components U.S. DOT - Appendix A Table 1 - Reportable Quantities DEXTRORPHAN-D-TARTRATE Not Listed TDG (Canada): WHMIS hazard class: Non-controlled IMDG/IMO IMDG - Hazard Classifications Not Applicable Components U.S. DOT - Appendix B - Marine Pollutan U.S. DOT - Appendix B - Severe Marine Pollutants DEXTRORPHAN-D-TARTRATE Not Listed Not Listed IMO-labels: 15. REGULATORY INFORMATION International Inventories Catalog Number: 153741 Components DEXTRORPHAN-D-TARTRATE Product name: DEXTRORPHAN-D-TARTRATE Page 4 of 5 www.mpbio.com MP Biomedicals, LLC U.S. regulations: Components California Proposition 65 - Massachusetts Right to Know List: New Jersey Right to Know List: Pennsylvania Right to Know List: DEXTRORPHAN-DTARTRATE Not Listed Not Listed Not Listed Not Listed Components Florida substance List: Rhode Island Right to Know List: Illinois - Toxic Air Contaminants Connecticut - Hazardous Air Pollutants DEXTRORPHAN-DTARTRATE Not Listed Not Listed Not Listed Not Listed Components SARA 313 Emission reporting/Toxic Release of Chemicals CERCLA/SARA - Section 302 Extremely Haz NTP: IARC: DEXTRORPHAN-DTARTRATE Not Listed Not Listed None None SARA 313 Notification: The above is your notification as to the SARA 313 listing for this product(s) pursuant to Section 313 of Title III of the Superfund Ammendments and Reauthorization Act of 1986 and 40 CFR Part 372. If you are unsure if you are subject to the reporting requirements of Section 313, or need more information, please call the EPA Emergency Planning and Community Right-To-Know Information Hotline: (800) 535-0202 or (202) 479-2499 (in Washington, DC or Alaska). State Notification: The above information is your notice as to the Right-to-Know listings of the stated product(s). Individual states will list chemicals for a variety of reasons including, but not limited to, the compounds toxicity; carcinogenic, tumorigenic and/or reproductive hazards; and the compounds environmental impact if accidentally released. 16. OTHER INFORMATION Prepared by: Health & Safety Disclaimer: The information and recommendations contained herein are based upon tests believed to be reliable. However, MP Biomedicals does not guarantee the accuracy or completeness NOR SHALL ANY OF THIS INFORMATION CONSTITUTE A WARRANTY, WHETHER EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE GOODS, THE MERCHANTABILITY OF THE GOODS, OR THE FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE. Adjustment to conform to actual conditions of usage maybe required. MP Biomedicals assumes no responsibility for results obtained or for incidental or consequential damages, including lost profits arising from the use of these data. No warranty against infringement of any patent, copyright or trademark is made or implied. End of Safety Data Sheet EU EINECS List - 204-754-3; C17H23NO Not Listed Catalog Number: 153741 Canada DSL Inventory List - Not Listed Product name: DEXTRORPHAN-D-TARTRATE Page 5 of 5 Inventory - United States TSCA - Sect. 8(b)